Results 91 to 100 of about 1,603,272 (276)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Colour analysis and discrimination of laboratory prepared pasta by means of spectroscopic methods

open access: yesCzech Journal of Food Sciences, 2011
For the CIE Lab colour profile determination of laboratory prepared pasta, two sample granulations and two spectral methods were tested. Pasta was manufactured progressively from semolina, common wheat, and corn flour.
Marie Hrušková   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Two-wave sensor for remote selection of natural surfaces

open access: yesТехнологія та конструювання в електронній апаратурі, 2005
A sensor based on the active two-wave method of recognizing natural surfaces has been developed. The proposed method simplifies the determination of the reflective properties of a surface and reduces the error of range measurements.
I. A. Ivanchenko   +2 more
doaj  

A trust region spectral method for large-scale systems of nonlinear equations

open access: yesJournal of Inequalities and Applications, 2016
The spectral gradient method is one of the most effective methods for solving large-scale systems of nonlinear equations. In this paper, we propose a new trust region spectral method without gradient.
Meilan Zeng, Guanghui Zhou
doaj   +1 more source

Unsupervised Multitaper Spectral Method for Identifying REM Sleep in Intracranial EEG Recordings Lacking EOG/EMG Data. [PDF]

open access: yesBioengineering (Basel), 2023
Lepage KQ   +4 more
europepmc   +1 more source

Filtering the Tau method with Frobenius-Pad\'e Approximants

open access: yes, 2017
In this work, we use rational approximation to improve the accuracy of spectral solutions of differential equations. When working in the vicinity of solutions with singularities, spectral methods may fail their propagated spectral rate of convergence and
A., José M.   +5 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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