Results 51 to 60 of about 181,239 (315)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Spectral State Space Models

, 2023
This paper studies sequence modeling for prediction tasks with long range dependencies. We propose a new formulation for state space models (SSMs) based on learning linear dynamical systems with the spectral filtering algorithm (Hazan et al. (2017)).
Agarwal, Naman, Suo, Daniel, Chen, Xinyi, Hazan, Elad   +3 more
openaire   +2 more sources

Research on Space Targets Simulation Modulation Algorithm Combined Global–Local Multi-Spectral Radiation Features

Sensors
To solve the international problem of global–local radiation features simulation of multi-spectral space targets, this paper proposes a multi-spectral space target simulation modulation algorithm that can combine global–local spectral radiation features.
Yu Zhang, Songzhou Yang, Zhipeng Wei, Jian Zhang, Bin Zhao, Dianwu Ren, Jingrui Sun, Lu Wang, Taiyang Ren, Dongpeng Yang, Guoyu Zhang   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

H-spectral spaces

Topology and its Applications, 2006
A compact and sober topological space \(X\) is called spectral if the family of compact open sets of \(X\) is closed under finite intersections and forms a basis of \(X.\) The author obtains some partial results concerning the following question: For which \(T_0\)-spaces \(X\) is a construction due to Herrlich, which is called the \(T_0 ...
openaire   +2 more sources

Space-borne Aerosol cloud High Spectral Resolution Lidar [PDF]

EPJ Web of Conferences
The main spaceborne Payload ACDL (Aerosol and Carbon dioxide Detection Lidar) has been launched, tested and working in the 705 km orbit has three detection methods (HSRL, depolarization and energy detection), four laser wavelengths, five detection ...
Bi Decang, Hu Jianbo, Liu Jiqiao, Ma Xiuhua, Xin Fengxin, Wu Songhua, Dai Guangyao, Long Wenrui, Biao-Chen Wei   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Simulating and Validating CHIME and LSTM Data for Urban Material Characterization

Remote Sensing
The aim of this research is to investigate potential uses of the CHIME and LSTM missions for urban climate research. Therefore, this paper initially introduces two methodologies to obtain synthetic images for these future ESA missions starting from ...
Leonel Garro Linck, Antonietta Sorriso, Paolo Gamba, Panagiotis Sismanidis, Iphigenia Keramitsoglou, Chris T. Kiranoudis, Jürgen Fischer   +6 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source