Results 51 to 60 of about 180,935 (266)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Space-borne Aerosol cloud High Spectral Resolution Lidar [PDF]

EPJ Web of Conferences
The main spaceborne Payload ACDL (Aerosol and Carbon dioxide Detection Lidar) has been launched, tested and working in the 705 km orbit has three detection methods (HSRL, depolarization and energy detection), four laser wavelengths, five detection ...
Bi Decang, Hu Jianbo, Liu Jiqiao, Ma Xiuhua, Xin Fengxin, Wu Songhua, Dai Guangyao, Long Wenrui, Biao-Chen Wei   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The AGN nature of strong C III] emitters in the early Universe with JWST

Astronomy & Astrophysics
The semi-forbidden C III] λλ1907,1909 doublet is a key tracer of high-ionisation emission in the early Universe. We present a study of C III] emission in galaxies at z = 5 − 7, using publicly available JWST/NIRSpec prism data from programmes including ...
Arevalo-Gonzalez F., Tripodi R., Llerena M., Pentericci L., Plat A., Barro G., Amorín R. O., Backhaus B., Calabrò A., Cleri N. J., Dickinson M., Dunlop J. S., Finkelstein S. L., Giavalisco M., Hirschmann M., Kartaltepe J., Koekemoer A. M., Lucas R. A., Napolitano L., Piconcelli E., Taylor A. J., Tombesi F., Trump J. R., Wang X.   +23 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Simulating and Validating CHIME and LSTM Data for Urban Material Characterization

Remote Sensing
The aim of this research is to investigate potential uses of the CHIME and LSTM missions for urban climate research. Therefore, this paper initially introduces two methodologies to obtain synthetic images for these future ESA missions starting from ...
Leonel Garro Linck, Antonietta Sorriso, Paolo Gamba, Panagiotis Sismanidis, Iphigenia Keramitsoglou, Chris T. Kiranoudis, Jürgen Fischer   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Passive Vibration Control Method of Modular Space Structures Based on Band Gap Optimization

International Journal of Aerospace Engineering, 2022
Modular space structure has become a research hotspot in the aerospace field. In the microgravity and weak damping space environment, modular space structures may continuously vibrate due to the transient excitation caused by satellite attitude ...
Juntao Zhu, Tuanjie Li, Bo Li, Yaqiong Tang, Zuowei Wang, Qingjuan Duan   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The Optical System Design of a Space-Based Wide-Field Infrared Slitless Spectrometer

Photonics
With the increasingly complex space environment, the operational safety of spacecraft faces severe challenges, creating an urgent need to develop efficient and reliable space target detection and identification technologies. Traditional optical detection
Yue Chen, Liang Zhou, Peiquan Chen, Pengkai Dong, Haiyang Zhang, Wenji She   +5 more
doaj   +1 more source