The loss of βΙ spectrin alters synaptic size and composition in the ja/ja mouse
Frontiers in NeuroscienceIntroductionDeletion or mutation of members of the spectrin gene family contributes to many neurologic and neuropsychiatric disorders. While each spectrinopathy may generate distinct neuropathology, the study of βΙ spectrin’s role (Sptb) in the brain has
Michael C. Stankewich +3 more
doaj +1 more source
Label-free microfluidic enrichment of ring-stage Plasmodium falciparum-infected red blood cells using non-inertial hydrodynamic lift [PDF]
, 2014 <b>Background</b> Understanding of malaria pathogenesis caused by Plasmodium falciparum has been greatly deepened since the introduction of in vitro culture system, but the lack of a method to enrich ring-stage parasites remains a technical ...
Chan, Sherwin +5 more
core +1 more source
Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage
International Journal on Biological Sciences, 2016 The ubiquitously expressed β2-spectrin (β2SP, SPTBN1) is the most common non-erythrocytic member of the β-spectrin gene family. Loss of β2-spectrin leads to defects in liver development, and its haploinsufficiency spontaneously leads to chronic liver ...
H. Baek +7 more
semanticscholar +1 more source
Cotranslational folding of proteins on the ribosome.
, 2020 Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core +1 more source
A New method for the capture of surface proteins in Plasmodium falciparum parasitized erythrocyte [PDF]
, 2012 Introduction: We propose a new method for the selective labeling, isolation and electrophoretic analysis of the Plasmodium falciparum protein exposed on the erythrocyte cell surface.
Ferru, Emanuela +2 more
core
Loop-closure events during protein folding: Rationalizing the shape of Phi-value distributions
, 2005 In the past years, the folding kinetics of many small single-domain proteins has been characterized by mutational Phi-value analysis. In this article, a simple, essentially parameter-free model is introduced which derives folding routes from native ...
Weikl, Thomas R.
core +1 more source
The Spectrin cytoskeleton regulates the Hippo signalling pathway
EMBO Journal, 2015 The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show that the Spectrin cytoskeleton controls Hippo signalling.
G. Fletcher +5 more
semanticscholar +1 more source
Properties of brain spectrin (fodrin)
FEBS Letters, 1983 Fodrin, a protein from bovine brain, immunologically related to spectrin, is shown, unlike some other proteins of generally similar appearance in the electron microscope, to resemble spectrin closely in its most distinctive structural characteristic, the very high α‐helix content. Like spectrin, it is also insoluble below pH 5. One of the subunits only
Burns, N.R., Ohanian, V., Gratzer, W.B.
openaire +2 more sources
Surface Polymer Network Model and Effective Membrane Curvature Elasticity
, 1995 A microscopic model of a surface polymer network - membrane system is introduced, with contact polymer surface interactions that can be either repulsive or attractive and sliplinks of functionality four randomly distributed over the supporting membrane ...
B. Duplantier +19 more
core +1 more source
Spectrin regulates Hippo signaling by modulating cortical actomyosin activity
eLife, 2015 The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this pathway is regulated in development remains a major challenge.
Hua Deng +5 more
semanticscholar +1 more source