Results 51 to 60 of about 1,366,012 (305)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Determination of Antimony in Gold-Antimony Ore and Antimony Ore by Inductively Coupled Plasma-Atomic Emission Spectrometry with Four Acids Dissolution

Yankuang ceshi, 2013
There are reliable chemical analysis methods for determining high, low and trace amounts of antimony in gold-antimony ore and antimony ore. However, the volumetric method for low content antimony measurements has a low analysis efficiency and involves a ...
WEI Yi, DOU Xiang-li, JU Li-pei, ZHANG Wang-qiang, ZHAO Wei-hua, YU Zhi-feng, MAO Zheng-cai   +6 more
doaj  

Probing the Composition, Assembly and Activity of Protein Molecular Machines using Native Mass Spectrometry [PDF]

, 2017
Native mass spectrometry and mass spectrometry in general, are powerful analytical tools for studying proteins and protein complexes. Native mass spectrometry may provide accurate mass measurements of large macromolecular assemblies enabling the ...
van de Waterbeemd, M.J., Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics   +2 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A MASSive laboratory tour. An interactive mass spectrometry outreach activity for children [PDF]

, 2013
It is imperative to fascinate young children at an early stage in their education for the analytical sciences. The exposure of the public to mass spectrometry presently increases rapidly through the common media. Outreach activities can take advantage of
Jungmann, JH, Mascini, N.E., Heeren, R.M.A., Afd Scheikunde Algemeen, Smith, D.F., Sub Biomol.Mass Spectrometry & Proteom., Cillero-Pastor, B., Biomolecular Mass Spectrometry and Proteomics, Eijkel, G.B., Kiss, A., Chughtai, S., Duursma, M.C., Klinkert, I., Dep Scheikunde, Chughtai, K   +14 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Characteristics of Luminescence from High-Temperature- and High-Pressure-Treated Diamonds

Applied Sciences
High-temperature and high-pressure (HTHP)-treated diamonds have attracted attention all over the world due to their vivid colors. In order to explore a new method for the rapid and non-destructive identification of HTHP-treated diamonds, in this paper ...
Mu-Lin Huang, Xue-Mei He, Ming-Yue Du, Peng-Fei Jiang, Xue-Feng Wang   +4 more
doaj   +1 more source

Remote Sensing of Chlorophyll Fluorescence in the Ocean Using Imaging Spectrometry: Toward a Vertical Profile of Fluorescence

Geophysical Research Letters, 2019
Chlorophyll fluorescence measurements provide valuable information on phytoplankton abundance and physiology. High spectral resolution measurements from the aircraft‐mounted Portable Remote Imaging SpectroMeter (PRISM) allow for a more robust and ...
Z. K. Erickson, C. Frankenberg, D. R. Thompson, A. F. Thompson, M. Gierach   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source