Results 31 to 40 of about 1,444,424 (305)

Maximizing analytical precision: exploring the advantages of ratiometric strategy in fluorescence, Raman, electrochemical, and mass spectrometry detection

Frontiers in Analytical Science, 2023
Ratiometric strategy are an invaluable method that helps to detect and quantify analytes. This approach relies on measuring changes in the ratio of two or more signals to improve the accuracy and sensitivity of the results.
Manivannan Madhu, S. Santhoshkumar, Wei-Bin Tseng, Wei-Lung Tseng, Wei-Lung Tseng   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

X-Ray Fluorescence Spectrometry as a Cultural Resource Management Tool

Advances in Archaeological Practice
Energy-dispersive X-ray fluorescence (XRF) spectrometry is commonly used by archaeologists and museum staff to nondestructively characterize the elemental composition of artifacts or other materials of cultural relevance, ranging from obsidian and other ...
Kyle P. Freund, Lucas R. M. Johnson, Jeremias M. Pink, Joshua G. Clements, Mark Toussaint   +4 more
doaj   +1 more source

Simple procedure for nutrient analysis of coffee plant with energy dispersive X-ray fluorescence spectrometry (EDXRF)

Scientia Agricola, 2013
Nutrient analysis is used to estimate nutrient content of crop plants to manage fertilizer application for sustained crop production. Direct solid analysis of agricultural and environmental samples by energy dispersive X-ray fluorescence spectrometry ...
Tiago Tezotto, José Laércio Favarin, Ana Paula Neto, Priscila Lupino Gratão, Ricardo Antunes Azevedo, Paulo Mazzafera   +5 more
doaj   +1 more source

X-ray Fluorescence Analysis of Waste Sm-Co Magnets: A Rational Approach

Recycling, 2023
Determination of the chemical composition of waste Sm-Co magnets is required for their efficient recycling. The non-stereotypical composition of said magnets makes an analysis extremely challenging.
Alexandra Alexandrovna Arkhipenko, Galina Evgenievna Marina, Marina Sergeevna Doronina, Natalya Alexandrovna Korotkova, Vasilisa Borisovna Baranovskaya   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Use of fluorescence imaging and spectrometry in detection of oral squamous cell carcinoma and oral potentially malignant disorders

Oral Oncology Reports
Objective: Changes in the autofluorescence of cancerous tissue in comparison to normal tissue due to alteration in the endogenous fluorophores and protein like NAD and FAD has been utilized in various oral cancer screening devices.
Vivek Nayyar, Pramila Thapa, Dalip Singh Mehta, Rahul Yadav, Krushna Bhatt, Varun Surya, Deepika Mishra   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source