Results 41 to 50 of about 1,366,012 (305)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Active learning for convenient annotation and classification of secondary ion mass spectrometry images [PDF]

, 2013
Digital staining for the automated annotation of mass spectrometry imaging (MSI) data has previously been achieved using state-of-the-art classifiers such as random forests or support vector machines (SVMs).
Köthe, U., Heeren, R.M.A., Hamprecht, F.A., Renard, B.Y., Hanselmann, M., Röder, J., Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics   +7 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Innovation and Development for Atomic Fluorescence Spectrometry Analysis

Yankuang ceshi, 2013
Atomic fluorescence spectrometry (AFS) has such characteristics of chemical vapor separation and non dispersive optical system. It is one of the most successful analytical methods available to determine trace As, Sb, Bi, Hg, Se, Te and Ge elements ...
LI Gang, HU Si-xian, CHEN Lin-ling
doaj  

Geochemical Characteristics of Selenium in Surface Soil of Central Townships in Zhaojue County, Sichuan Province

Yankuang ceshi, 2022
BACKGROUND Selenium (Se) is one of the essential trace elements for humans, and an important way for humans to obtain and supplement selenium is by eating natural selenium-enriched agricultural products. The geochemical characteristics of selenium in the
ZHAO Chen, SUN Binbin, HE Ling, WU Chao, CHENG Xiaomeng, ZENG Daoming, LIU Dong   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Effect of Hydrostatic Pressure on the Fluorescence of Tryptophan in the Presence of Metal Ions Running title: Effect of pressure on the tryptophan

Brazilian Archives of Biology and Technology, 2018
The effect of pressure on the fluorescence of tryptophan in the presence of metal ions was studied by fluorescence spectrometry. It was found that at 60 MPa, the fluorescence intensity of M/Trp mixtures (M represented metal ions) increased compared to ...
Chengman Bao, Xinhui Tang, Shuming Ye
doaj   +1 more source

Foliar Elemental Analysis of Brazilian Crops via Portable X-ray Fluorescence Spectrometry

Sensors, 2020
Foliar analysis is very important for the nutritional management of crops and as a supplemental parameter for soil fertilizer recommendation. The elemental composition of plants is traditionally obtained by laboratory-based methods after acid digestion ...
Camila S. Borges, David C. Weindorf, Geila S. Carvalho, Luiz R. G. Guilherme, Thalita Takayama, Nilton Curi, Geraldo J. E. O. Lima, Bruno T. Ribeiro   +7 more
doaj   +1 more source

Autofluorescence as a noninvasive biomarker of senescence and advanced glycation end products in Caenorhabditis elegans

npj Aging and Mechanisms of Disease, 2021
To assess the utility of autofluorescence as a noninvasive biomarker of senescence in Caenorhabditis elegans, we measured the autofluorescence of individual nematodes using spectrofluorometry. The fluorescence of each worm increased with age.
Tomomi Komura, Mikihiro Yamanaka, Kohji Nishimura, Keita Hara, Yoshikazu Nishikawa   +4 more
doaj   +1 more source