Results 101 to 110 of about 198,485 (311)

Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level. [PDF]

, 2018
‘A picture is worth a thousand words’ is an idiom from the English language (‘borrowed’ from on old Chinese proverb) that conveys the notion that a complex idea can be succinctly and fully described by a single image. Never has this expression been truer
Andrén, PE, Caprioli, RM, Castellino, S, Charkoftaki, G, Duncan, MW, Goodwin, RJA, Johnson, CH, Rattray, NJW, Schey, KL, Shahidi-Latham, SK, Vasiliou, V, Veselkov, KA   +11 more
core   +3 more sources

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells

Journal of Lipid Research, 2006
Maturation of fetal alveolar type II epithelial cells in utero is characterized by specific changes to lung surfactant phospholipids. Here, we quantified the effects of hormonal differentiation in vitro on the molecular specificity of cellular and ...
Anthony D. Postle, Linda W. Gonzales, Wolfgang Bernhard, Graeme T. Clark, Marye H. Godinez, Rodolfo I. Godinez, Philip L. Ballard   +6 more
doaj   +1 more source

High Sensitivity Mass Spectrometric Quantification of Serum Growth Hormone by Amphiphilic Peptide Conjugation [PDF]

, 2012
Amphiphilic peptide conjugation affords a significant increase in sensitivity with protein quantification by electrospray-ionization mass spectrometry.
Arsene, Arsene, Barkan, Busch, Cech, Cech, Chai, Chanson, Foettinger, Frahm, Giustina, Halquist, Hofmann, Kulevich, Ligon, Litterscheid, Markkanen, Mirzaei, Shortreed, Shuford, Ullmer, Williams, Williams, Wu, Yang, Yang   +25 more
core   +1 more source

Long‐Tea‐CLIP: An Expert‐Level Multimodal AI Framework for Fine‐Grained Green Tea Grading Across Five Sensory Dimensions

Advanced Science, EarlyView.
Long‐Tea‐CLIP (Contrastive Language‐Image Pre‐training) presents a multimodal AI framework that integrates visual, metabolomic, and sensory knowledge to grade green tea across appearance, soup color, aroma, taste, and infused leaf. By combining expert‐guided modeling with CLIP‐supervised learning, the system delivers fine‐grained quality evaluation and
Yanqun Xu, Zhengfang Xue, Qing Luo, Xu Liu, Yongquan Xu, Jing Huang, Xingcai Zhang, Xinyuan Zhang, Zhonghua Liu, Zisheng Luo   +9 more
wiley   +1 more source

Metabolomics : a tool for studying plant biology [PDF]

, 2005
In recent years new technologies have allowed gene expression, protein and metabolite profiles in different tissues and developmental stages to be monitored.
Gullberg, Jonas
core  

Vibrational signatures of gaseous Meisenheimer complexes bonded at carbon and nitrogen [PDF]

, 2017
Anionic adducts of 1,3,5-trinitrobenzene (TNB) with deprotonated pyrrolidine (Pyr), imidazole (Im), acetone (Ac) and acetylacetone (Acac) have been delivered into the gas phase by electrospray ionization.The so-formed ions, TNB-Nu−(Nu = Pyr, Im, Ac, Acac)
Chiavarino, Barbara, Crestoni, Maria Elisa, Fornarini, Simonetta   +2 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Espectrometria de massas com ionização por "electrospray": processos químicos envolvidos na formação de íons de substâncias orgânicas de baixo peso molecular

Química Nova, 2006
An overview of the current literature on the chemical processes involved in the ion formation from low molecular weight organic compounds by electrospray ionization mass spectrometry is given.
Crotti Antônio Eduardo Miller, Vessecchi Ricardo, Lopes João Luis Callegari, Lopes Norberto Peporine   +3 more
doaj  

Model mass spectrometric study of competitive interactions of antimicrobial bisquaternary ammonium drugs and aspirin with membrane phospholipids [PDF]

, 2013
The aim of the study is to reveal molecular mechanisms of possible activity modulation of antimicrobial bis-quaternary ammonium compounds (BQAC) and aspirin (ASP) through noncovalent competitive complexation under their combined introduction into the ...
Gömöry, Ágnes, Kosevich, M. V., Pashynska, V. A., Vékey, Károly   +3 more
core   +2 more sources