Results 211 to 220 of about 198,485 (311)

Continuous Flow Paper Spray Ionization Mass Spectrometry for In-Depth Characterization of Anticancer Drugs in Tissues: Addressing Mass Spectral Complexity. [PDF]

J Am Soc Mass Spectrom
Basuri P, Klinghammer K, Klein O, Volmer DA.   +3 more
europepmc   +1 more source

Prism[5]MaxQ: A Sulfated Prism[5]Arene and Its Molecular Recognition Properties Toward a Panel of Quaternary Ammonium Guests

Chemistry – A European Journal, EarlyView.
We report the synthesis and characterization of a sulfated prism[5]arene host (Prism[5]MaxQ). Prism[5]MaxQ displays ultrahigh binding affinity (Ka up to 1012 M−1) toward hydrophobic (di)cations in phosphate‐buffered saline (PBS). The work positions Prism[5]MaxQ as a new member of the family of ultrahigh‐affinity hosts poised for use as a sequestrant in
Emmanuel A. Bazan‐Bergamino, Lyle Isaacs   +1 more
wiley   +1 more source

Development and Validation of SEC-UV/HRMS Procedure for Simultaneous Determination of BSA and Its Association Products. [PDF]

Molecules
Hodnik B, Čamič Ž, Pompe M.
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Time-Resolved Native Mass Spectrometry for Direct Measurement of Biomolecular Kinetics. [PDF]

J Am Chem Soc
James VK, Stover L, Bahramimoghaddam H, Khandelwal T, Chang JY, Downing J, Scott E, Bailey KO, Russell DH, Baker LA, Laganowsky A.   +10 more
europepmc   +1 more source

Charge State Influence on Stability and Isomerism in Dehydrogenated PAHs: Insights from Anthracene, Acridine, and Phenazine

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
The ionization of anthracene, acridine, and phenazine has been explored, along with the removal of one and two hydrogen atoms, to provide valuable information for astrochemists and to understand the behavior of the resulting structures and their electronic reorganization. Abstract In this study, we systematically explored the stability and isomerism of
Khaldia Zghida, Farouk Hamza Reguig, Manuel Alcamí, Al Mokhtar Lamsabhi   +3 more
wiley   +1 more source

Native mass spectrometry enabled by infrared matrix-assisted laser desorption electrospray ionization for rapid measurement of protein-ligand biophysical parameters. [PDF]

Anal Bioanal Chem
Adepoju AA, Ghiladi RA, Muddiman DC.
europepmc   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Future perspectives in mass spectrometry of plant lipids. [PDF]

Planta
Gutbrod K, Dörmann P.
europepmc   +1 more source

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source