Results 231 to 240 of about 296,165 (332)

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka   +12 more
wiley   +1 more source

Spatially Resolved Plant Metabolomics. [PDF]

open access: yesMetabolites
Myers RJ   +14 more
europepmc   +1 more source

Rapid Identification of New Psychoactive Substances in Letters by LA‐APCI‐MS

open access: yesDrug Testing and Analysis, EarlyView.
Laser ablation coupled to molecular mass spectrometry utilizing a modified atmospheric pressure chemical ionization source was used for the detection of synthetic cannabinoid receptor agonists in infused prison mail samples. ABSTRACT New psychoactive substances (NPS), especially synthetic cannabinoid receptor agonists (SCRA), are increasingly smuggled ...
Mark Wesner   +4 more
wiley   +1 more source

Simulation of the Metabolism of New Psychoactive Substances Using Electrochemistry‐Mass Spectrometry: Introducing an Innovative Software Tool for Rapid Data Evaluation

open access: yesDrug Testing and Analysis, EarlyView.
A novel software tool for the rapid and efficient simulation of the metabolism of new psychoactive substances was developed and applied to mimic the metabolism of the synthetic cannabinoid receptor agonist MDMB‐4en‐PINACA. ABSTRACT An innovative software tool for the rapid and efficient simulation of the metabolism of new psychoactive substances (NPS ...
Mark Wesner   +3 more
wiley   +1 more source

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites

open access: yesDrug Testing and Analysis, EarlyView.
Well‐characterized, chemically synthesized molecules related to LGD‐4033 metabolism were used as analytical standards for the analysis of LGD‐4033 post‐administration urine samples. This approach offered further insights into LGD‐4033 metabolism, providing solid experimental proof for the structure of important previously reported metabolites and ...
Yiannis S. Angelis   +5 more
wiley   +1 more source

Metabolic changes during cardiac regeneration in the axolotl

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich   +10 more
wiley   +1 more source

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