Results 41 to 50 of about 70,524 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Molecular weight fractionation and as binding mechanisms of dissolved organic matter in tea plantation soils

Ecotoxicology and Environmental Safety
Understanding the molecular-scale heterogeneity of dissolved organic matter (DOM) in tea plantation soils is essential for explaining regional differences in tea quality and mitigating contaminant risks.
Youru Yao, Yanhao Li, Jie Fang, Chonghong Zhang, Lian Sun, Huarong Tan, Zichen Li, Yuesheng Lin, Xiaohan Wang, Pingjiu Zhang   +9 more
doaj   +1 more source

Spectroscopic characteristics of humic acids originated in soils and lignite

Soil and Water Research, 2009
The aim of our work was to characterise the stability, humification degree, and principal classes of fluorophores in humic acids isolated from different matrices.
Ľubica POSPÍŠILOVÁ, Naděžda FASUROVÁ   +1 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

1H- and 13C-NMR Analysis of a Series of 1,2-Diaryl-1H-4,5-dihydroimidazoles

Molecules, 2005
An analysis of the 1H- and 13C-NMR spectra of a series of 1,2-diaryl-1H-4,5-dihydroimidazoles and comparisons with 4,5-dihydroimidazoles having differentsubstitution patterns are presented.
Isabel A. Perillo, Alejandra Salerno
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Geometry-Dependent Spectroscopic Contrast in Deep Tissues

iScience, 2019
Summary: Nano-structures of biological systems can produce diverse spectroscopic effects through interactions with broadband light. Although structured coloration at the surface has been extensively studied, natural spectroscopic contrasts in deep ...
Xin Ge, Hongying Tang, Xianghong Wang, Xinyu Liu, Si Chen, Nanshuo Wang, Guangming Ni, Xiaojun Yu, Shufen Chen, Haitao Liang, En Bo, Lulu Wang, Cilwyn Shalitha Braganza, Chenjie Xu, Steven M. Rowe, Guillermo J. Tearney, Linbo Liu   +16 more
doaj   +1 more source

Vibrational spectroscopic, linear and nonlinear optical characteristics of Anthocyanin extracted from blueberry

Results in Optics, 2020
A natural pigment Anthocyanin, extracted from blueberry, has been reported in this paper. The structure of blueberry powder was studied by X-ray diffraction (XRD) and it divulges that the prepared powder seems to be amorphous. Fourier transform infrared (
Sivanukkalai Jeyaram, Thankappan Geethakrishnan   +1 more
doaj   +1 more source