Results 51 to 60 of about 478 (248)

New Type of Sturm-Liouville Problems in Associated Hilbert Spaces

open access: yesJournal of Function Spaces, 2014
We introduce a new type of discontinuous Sturm-Liouville problems, involving an abstract linear operator in equation. By suggesting own approaches we define some new Hilbert spaces to establish such properties as isomorphism, coerciveness, and maximal ...
O. Sh. Mukhtarov, K. Aydemir
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Hill's equation for a homogeneous tree

open access: yesElectronic Journal of Differential Equations, 1997
The analysis of Hill's operator $-D^2 + q(x)$ for $q$ even and periodic is extended from the real line to homogeneous trees ${cal T}$. Generalizing the classical problem, a detailed analysis of Hill's equation and its related operator theory on $L^2({cal
Robert Carlson
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A Note on Property (gb) and Perturbations

open access: yesAbstract and Applied Analysis, 2012
An operator T∈ℬ(X) defined on a Banach space X satisfies property (gb) if the complement in the approximate point spectrum σa(T) of the upper semi-B-Weyl spectrum σSBF+-(T) coincides with the set Π(T) of all poles of the resolvent of T. In this paper, we
Qingping Zeng, Huaijie Zhong
doaj   +1 more source

On the bounded invertibility of a Schr¨odinger operator with a negative parameter in the space L2(Rn )

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2019
The Schrödinger operator L = -∆ + q ( x ) , x ∈ Rn, is one of the main operators of modern quantum mechanics and theoretical physics. It is known that many fundamental results have been obtained for the Schrödinger operator L .
M.B. Muratbekov, M.M. Muratbekov
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Spectral Distribution of Transport Operator Arising in Growing Cell Populations

open access: yesJournal of Function Spaces, 2014
Transport equation with partly smooth boundary conditions arising in growing cell populations is studied in Lp ...
Hongxing Wu, Shenghua Wang, Dengbin Yuan
doaj   +1 more source

Gevrey-Type Resolvent Estimates at the Threshold for a Class of Non-Selfadjoint Schrödinger Operators

open access: yesBruno Pini Mathematical Analysis Seminar, 2015
In this article, we show that under some coercive assumption on the complex-valued potential V(x), the derivatives of the resolvent of the non-selfadjoint Schröinger operator H = −∆ + V(x) satisfy some Gevrey estimates at the threshold zero.
Xue Ping Wang
doaj   +1 more source

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