Results 61 to 70 of about 499 (268)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Rotationally resolved zero-kinetic-energy photoelectron spectrum of nitrogen
Physical Review A, 1992 Rotationally resolved zero-kinetic-energy (ZEKE) photoelectron spectra of the X $^{2}\mathrm{\ensuremath{\Sigma}}_{\mathrm{g}}^{+}$(${\mathrm{v}}^{+}$=0,1) \ensuremath{\leftarrow}X $^{1}\mathrm{\ensuremath{\Sigma}}_{\mathit{g}}^{+}$(v=0) bands of nitrogen have been recorded. The spectra show unexpected rotational-line intensities.
Merkt, F, Softley, T
openaire +5 more sources
Weyl-Titchmarsh theory for Sturm-Liouville operators with distributional potentials [PDF]
Opuscula Mathematica, 2013 We systematically develop Weyl-Titchmarsh theory for singular differential operators on arbitrary intervals \((a,b) \subseteq \mathbb{R}\) associated with rather general differential expressions of the type \begin{equation*}\tau f = \frac{1}{\tau} (-(p[f'
Jonathan Eckhardt +3 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
On continuous and residual spectra of operators connected with iterative functional equations
Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2006 The sum type operator $F$, given by [ F lbrack varphi brack (x) : = displaystylesum^{infty}_{u = 0} 2^{-u} varphi (2^{u} x), ] will be considered on the space $D$ of bounded real functions, equipped with the supremum norm and on its ...
Hans-Heinrich Kairies
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Topics on the spectral properties of degenerate non-self-adjoint differential operators
Journal of Inequalities and Applications, 2016 Let ( P u ) ( t ) = − d d t ( ω 2 ( t ) q ( t ) d u ( t ) d t ) $( Pu ) ( t ) =- \frac{d}{dt} ( \omega^{2} ( t ) q ( t ) \frac{du ( t )}{dt} )$ be a degenerate non-self-adjoint operator defined on the space H ℓ = L 2 ( 0 , 1 ) ℓ $H_{\ell} = L^{2} (0,1)^{\
Ali Sameripour, Yousef Yadollahi
doaj +1 more source
Commutable Matrix-Valued Functions and Operator-Valued Functions
Communications in Advanced Mathematical Sciences, 2020 A simple expression is established for an analytic commutable matrix-valued function. Then a characterization of two by two functional commutative matrices is proven.
Abdelaziz Maouche
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Linear and nonlinear abstract differential equations of high order
Open Mathematics, 2015 The nonlocal boundary value problems for linear and nonlinear degenerate abstract differential equations of arbitrary order are studied. The equations have the variable coefficients and small parameters in principal part.
Shakhmurov Veli B.
doaj +1 more source