Results 91 to 100 of about 37,610 (289)
Bipolar spectrum – A helpful concept?
, 2017 IntroductionMany patients seen in clinical practice have a mood disorder not well described by the existing diagnostic categories. Formally, they would be called “not otherwise specified” but this creates a huge single category for many patients that ...
T. Maia, P. Cabral Barata, J.C. Melo
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Inverse spectral problems for Sturm-Liouville operators with many frozen arguments
This study is devoted to the inverse spectral problems of the Sturm-Liouville operator with many frozen arguments. Under certain assumptions, the authors obtained the uniqueness theorems for recovering the operator from one spectrum. Finally, a numerical
Shieh Chung-Tsun; Tsai Tzong-Mo
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Baryonic Symmetries in AdS4/CFT3: An Overview
Advances in High Energy Physics, 2011 Global symmetries play an important role in classifying the spectrum of a gauge theory. In the context of the AdS/CFT duality, global baryon-like symmetries are specially interesting.
Diego Rodriguez-Gomez
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The Eddy Diffusivity in Barotropic β-Plane Turbulence
Fluids, 2017 Geostrophic turbulent eddies play a crucial role in the oceans, mixing properties such as heat, salt, and geochemical tracers. A useful reduced model for geostrophic turbulence is barotropic (2D) turbulence. The focus of this study is on 2D β -plane
Hailu Kong, Malte F. Jansen
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
International Journal of Communication, 2022 The advent of television technologies has significantly restructured the context within which community television producers operate. Digital technologies have undercut “spectrum scarcity” arguments for limiting access to distribution platforms and ...
Andrew Ó Baoill, Salvatore Scifo
doaj
Gaussian free fields at the integer quantum Hall plateau transition
Nuclear Physics B, 2017 In this work we put forward an effective Gaussian free field description of critical wavefunctions at the transition between plateaus of the integer quantum Hall effect.
R. Bondesan +2 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source