Results 101 to 110 of about 610,362 (284)

Cosmic infrared background excess from axion-like particles and implications for multi-messenger observations of blazars

, 2019
The first measurement of the diffuse background spectrum at 0.8-1.7 $\mu \rm{m}$ from the CIBER experiment has revealed a significant excess of the cosmic infrared background (CIB) radiation compared to the theoretically expected spectrum. We revisit the
Kalashev, Oleg E., Kusenko, Alexander, Vitagliano, Edoardo   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Looking for Strange Quark Matter in Cosmic Rays.

EPJ Web of Conferences, 2013
Usually it is supposed that the definition of the CR mass composition in knee region is the key to problem of CR spectrum modification in this range. However tens of the experiments were done for the last half of century and have not decided this problem
Bezshapov S.P., Shaulov S.B.
doaj   +1 more source

Comments on thermodynamics of supersymmetric matrix models

, 2008
We present arguments that the structure of the spectrum of the supersymmetric matrix model with 16 real supercharges in the large N limit is rather nontrivial, involving besides the natural energy scale ~\lambda^{1/3} = (g^2 N)^{1/3} also a lower scale ~\
A.V. Smilga, Aharony, Akhmedov, Anagnostopoulos, Banks, Basso, Becker, Beisert, Blok, Campostrini, Catterall, Catterall, de Wit, DeWit, Feynman, Frölich, Gubser, Gubser, Gubser, Halpern, Hanada, Hanada, Hoppe, Itzhaki, Kabat, Kac, Kawahara, Kawahara, Klebanov, Maldacena, Moore, Okawa, Paban, Porrati, Semenoff, Sethi, Smilga, Smilga, Smilga, Smilga, Smilga, Witten, Yi   +42 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Classical {\it vs.}\ Landau-Ginzburg Geometry of Compactification

, 1992
We consider superstring compactifications where both the classical description, in terms of a Calabi-Yau manifold, and also the quantum theory is known in terms of a Landau-Ginzburg orbifold model.
~Berglund, P., ~Greene, B. R., ~Hübsch, T.   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Linear second order elliptic partial differential equations with nonlinear boundary conditions at resonance without landesman-lazer conditions [PDF]

, 2014
We are concerned with the solvability of linear second order elliptic partial differential equations with nonlinear boundary conditions at resonance, in which the nonlinear boundary conditions perturbation is not necessarily required to satisfy Landesman-
Fadlallah, Alzaki
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source