Results 51 to 60 of about 1,648,498 (291)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Analysis of speech prosody using WaveNet embeddings : The Lombard effect [PDF]
, 2020 We present a novel methodology for speech prosody research based on the analysis of embeddings used to condition a convolutional WaveNet speech synthesis system.
Juraj Šimko +5 more
core +1 more source
Ибероамериканские тетради, 2016 Based on the data obtained in the project ‘Inmigrant Woman, Language and Society: New Perspectives for Integration”, which is being developed in the University of Vigo, we analyse the relations between the use of specific speech acts and the processes of
ÁNGEL Rodríguez Gallardo +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Prosodic Prominence and Boundaries in Sequence-to-Sequence Speech Synthesis [PDF]
, 2020 Recent advances in deep learning methods have elevated synthetic speech quality to human level, and the field is now moving towards addressing prosodic variation in synthetic speech.Despite successes in this effort, the state-of-the-art systems fall ...
Juraj Šimko +7 more
core +1 more source
SPEECH ACT ANALYSIS FOUND IN INSTAGRAM CAPTIONS OF "WHO INDONESIA”
Kajian Linguistik dan Sastra, 2021 Speech acts are utterances that contain action as a function of communication that considers aspects of the speech situation. The objective of this research is to analyze the type of speech act found in Instagram Captions of ‘WHO Indonesia”.
Tira Nur Fitria
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Conditional advice and inducements : are readers sensitive to implicit speech acts during comprehension? [PDF]
, 2011 Conditionals can implicitly convey a range of speech acts including promises, tips, threats and warnings. These are traditionally divided into the broader categories of advice (tips and warnings) and inducements (promises and threats). One consequence of
Stewart, Andrew J.; id_orcid +10 more
core +1 more source