Results 71 to 80 of about 1,648,498 (291)

Speech Acts and Translation

open access: yesZanco Journal of Humanity Sciences
This research explores the challenges in translating speech acts, particularly the differences between literal and idiomatic translations. The main research questions are: How do literal and idiomatic translations affect the understanding of speech acts?
Ahmed Qader Mohamedamin
doaj   +1 more source

A CRITICAL DISCOURSE ANALYSIS AND ILLOCUTIONARY ACTS OF JOHN MAY’S SPEECH IN THE DUKE OF EDINBURGH’S CEREMONY AWARD

open access: yesGetsempena English Education Journal, 2018
The aim of this article is to investigate John May’s speech in The Duke of Edinburgh’s ceremony awardin Indonesia. This study was designed based on descriptive qualitative research using critical discourse analysis approach, focusing on illocutionary ...
YesvikaFibry Prescilla, Resti Amalia
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

The Use of Speech Acts by Native and Non-Native Guests in Ellen Show: A Comparative Study

open access: yesRainbow: Journal of Literature, Linguistics and Culture, 2019
The aim of the study is to find out the type of illocutionary speech acts that used by native speakers and non-native speakers in Ellen Show. It also analyzes the identifier and the cross-cultural pragmatic background of the speeches.
Alisha Rahma Putri, Hendi Pratama
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

KESANTUNAN BERBAHASA DALAM TINDAK TUTUR PADA BUKU CERITA ANAK ABANGKU SAYANG KARYA MARION

open access: yesRetorika, 2017
Politeness in Speech Acts in Abangku Sayang" Story  Book Written by Marion. This study aims to describe the acts of speech and politeness in a book book of my beloved by Marion. The research used pragmatic approach with descriptive method.
Istiqamah Istiqamah
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

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