Results 71 to 80 of about 59,347 (306)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

A CRITICAL DISCOURSE ANALYSIS AND ILLOCUTIONARY ACTS OF JOHN MAY’S SPEECH IN THE DUKE OF EDINBURGH’S CEREMONY AWARD

open access: yesGetsempena English Education Journal, 2018
The aim of this article is to investigate John May’s speech in The Duke of Edinburgh’s ceremony awardin Indonesia. This study was designed based on descriptive qualitative research using critical discourse analysis approach, focusing on illocutionary ...
YesvikaFibry Prescilla, Resti Amalia
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

The Use of Speech Acts by Native and Non-Native Guests in Ellen Show: A Comparative Study

open access: yesRainbow: Journal of Literature, Linguistics and Culture, 2019
The aim of the study is to find out the type of illocutionary speech acts that used by native speakers and non-native speakers in Ellen Show. It also analyzes the identifier and the cross-cultural pragmatic background of the speeches.
Alisha Rahma Putri, Hendi Pratama
doaj   +1 more source

Intention and responsibility in speech acts [PDF]

open access: yes, 2014
I have argued elsewhere (Navarro-Reyes 2010) that the kind of excuses that appeal to a lack of intention in the performance of a speech act do not, in general, try to deny that the deed itself took place (i.e., in cases where we say that the act is ...
Navarro Reyes, Jesús   +1 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Speech Acts and Translation

open access: yesZanco Journal of Humanity Sciences
This research explores the challenges in translating speech acts, particularly the differences between literal and idiomatic translations. The main research questions are: How do literal and idiomatic translations affect the understanding of speech acts?
Ahmed Qader Mohamedamin
doaj   +1 more source

Speech Acts

open access: yes, 2017
Speech acts are acts that can, but need not, be carried out by saying and meaning that one is doing so. Many view speech acts as the central units of communication, with phonological, morphological, syntactic, and semantic properties of an utterance ...
Mitchell Green
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

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