Results 61 to 70 of about 59,347 (306)

Automatic twitter topic summarization with speech acts

, 2013
With the growth of the social media service of Twitter, automatic summarization of Twitter messages (tweets) is in urgent need for efficient processing of the massive tweeted information.
Ouyang, Y, Zhang, R, Li, W, Gao, D
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

QUANTUM MEASUREMENT ACT AS A SPEECH ACT [PDF]

Endophysics, Time, Quantum and the Subjective, 2005
I show that the quantum measurement problem can be understood if the measurement is seen as a ``speech act'' in the sense of modern language theory. The reduction of the state vector is in this perspective an intersubjectice -- or better a-subjective -- symbolic process. I then give some perspectives on applications to the ``Mind-Body problem''.
openaire   +2 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Speaker-independent emotion recognition exploiting a psychologically-inspired binary cascade classification schema [PDF]

, 2012
06.08.13 KB. Ok to add accepted version to spiral, embargo period expired. SpringerIn this paper, a psychologically-inspired binary cascade classification schema is proposed for speech emotion recognition.
Kotti, Margarita, Paternò, Fabio
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

SPECIFIC NATURE OF EVALUATIVE SPEECH ACTS

Novìtnâ Osvìta, 2018
 The article discusses the issues connected with the analysis of appearance of the evaluation in the utterance. Particular attention is paid to the illocutionary and perlocutionary effect of evaluative speech acts.
Ganna Prihodko
doaj   +1 more source

The Rhetorical Function of Interrupted Speech in Luke-Acts

, 2011
For at least ninety years, scholars have commented upon the presence of interrupted speech in the Acts of the Apostles. Despite the many references to interrupted speeches in commentaries and monographs, there have been very few attempts to discern what ...
Daniel Lynwood Smith (17553048)
core   +1 more source