Results 91 to 100 of about 319,390 (306)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Adaptation of Oxford Cognitive Screen into Turkish (OCS-TR): Validity and reliability study in stroke survivors

BMC Psychology
Background The existing cognitive screening tests used to assess cognitive disorders after stroke in Türkiye face limitations in scope and user applicability.
Özlem Oğuz, Bülent Toğram, Nele Demeyere   +2 more
doaj   +1 more source

Attention control comparisons with SLT for people with aphasia following stroke: methodological concerns raised following a systematic review [PDF]

, 2018
Objective: Attention control comparisons in trials of stroke rehabilitation require care to minimize the risk of comparison choice bias. We compared the similarities and differences in SLT and social support control interventions for people with aphasia.
Brady, Marian C., Campbell, Pauline, Elders, Andrew, Enderby, Pam, Godwin, Jon, Kelly, Helen   +5 more
core   +3 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Auditory Processing and Speech Sound Disorders: Behavioral and Electrophysiological Findings

Audiology Research
Background: Children diagnosed with Speech Sound Disorders (SSDs) encounter difficulties in speech perception, especially when listening in the presence of background noise.
Konstantinos Drosos, Paris Vogazianos, Dionysios Tafiadis, Louiza Voniati, Alexandra Papanicolaou, Klea Panayidou, Chryssoula Thodi   +6 more
doaj   +1 more source

Prevalence of compensatory misarticulation errors in children with cleft lip/palate

مجله پژوهش در علوم توانبخشی, 2012
Introduction: Cleft lip and/or cleft palate comprise a group of the structural disorders that can affect speech intelligibility and communicative functions.
Parisa Rezaei, Akhtarsadat Torabipour, Zahra Tavakoli, Leila Kargar   +3 more
doaj   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Communication Abilities, Assessment Procedures, and Intervention Approaches in Rett Syndrome: A Narrative Review

Brain Sciences
Background/Objectives: Rett syndrome (RTT) is a rare neurodevelopmental disorder that affects movement and communication skills primarily in females. This study aimed to synthesize the research from the last two decades regarding the verbal and nonverbal
Louiza Voniati, Angelos Papadopoulos, Nafsika Ziavra, Dionysios Tafiadis   +3 more
doaj   +1 more source

Speech therapy and general practice in Hong Kong [PDF]

, 1997
Speech therapy services in Hong Kong have changed dramatically in the past two decades. Further development is urgently required in three main areas; norms of speech and language development in Cantonese, descriptions of disordered communication in ...
Stokes, SF, Yiu, E
core  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source