Results 61 to 70 of about 173,179 (314)

Dysarthric speech classification from coded telephone speech using glottal features

open access: yes, 2021
This paper proposes a new dysarthric speech classification method from coded telephone speech using glottal features. The proposed method utilizes glottal features, which are efficiently estimated from coded telephone speech using a recently proposed ...
Alku, Paavo   +1 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Lombard speech synthesis using transfer learning in a Tacotron text-to-speech system

open access: yes, 2019
Currently, there is increasing interest to use sequence-to-sequence models in text-to-speech (TTS) synthesis with attention like that in Tacotron models.
Bajibabu Bollepalli   +5 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

How Much Voicing in Voiced Geminates? The Laryngeal Voicing Profile of Polish Double Stops

open access: yesArchives of Acoustics
Geminates (such as the double /k/ in Polish lekki “light”) form a group of consonants that are mainly characterized by longer durations than the corresponding singletons.
Arkadiusz ROJCZYK, Andrzej PORZUCZEK
doaj   +1 more source

Estimation of glottal closure instants in voiced speech using the DYPSA algorithm [PDF]

open access: yes, 2007
Published ...
Naylor, P A   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Associating the origin and spread of sound change using agent-based modelling applied to /s/-retraction in English

open access: yesGlossa, 2019
The study explored whether an asymmetric phonetic overlap between speech sounds could be turned into sound change through propagation around a community of speakers. The focus was on the change of /s/ to /ʃ/ which is known to be more likely than a change
Florian Schiel   +2 more
doaj   +2 more sources

Improving the Performance of Low-resourced Speaker Identification with Data Preprocessing

open access: yesJournal of ICT Research and Applications, 2023
Automatic speaker identification is done to tackle daily security problems. Speech data collection is an essential but very challenging task for under-resourced languages like Burmese.
Win Lai Lai Phyu   +2 more
doaj   +1 more source

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