Results 71 to 80 of about 3,919,398 (308)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Cooperative Encirclement Method Based on Delay-Robust Multi-Agent Reinforcement Learning

水下无人系统学报
To address delayed observations caused by acoustic communication in cooperative operations of multiple unmanned undersea vehicles(UUVs), a cooperative encirclement method based on delay-robust multi-agent reinforcement learning was proposed.
Songchen FU, Letian BAI, Shaojing ZHAO, Aomeng MENG, Hong LIANG, Ta LI   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Auditory and speech processing in specific language impairment (SLI) and dyslexia [PDF]

, 2009
This thesis investigates auditory and speech processing in Specific Language Impairment (SLI) and dyslexia. One influential theory of SLI and dyslexia postulates that both SLI and dyslexia stem from similar underlying sensory deficit that impacts ...
Tuomainen, O.T.
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The relationship between the coarticulatory source and effect in sound change: evidence from Italo-Romance metaphony in the Lausberg area

Laboratory Phonology
In ongoing sound changes, a coarticulatory effect is often enhanced as the coarticulatory source that gives rise to it wanes. But quite how phonologisation and these reciprocal coarticulatory changes are connected is still poorly understood.
Jonathan Harrington, Michele Gubian, Pia Greca   +2 more
doaj   +2 more sources

Wavelets for intonation modeling in HMM speech synthesis [PDF]

, 2013
The pitch contour in speech contains information about different linguistic units at several distinct temporal scales. At the finest level, the microprosodic cues are purely segmental in nature, whereas in the coarser time scales, lexical tones, word ...
Suni, Antti Santeri, Alku, Paavo, Vainio, Martti, Suni, Antti, Aalto, Daniel, Raitio, Tuomo   +5 more
core  

Avoiding distortions due to speech coding and transmission errors [PDF]

, 1999
We have extended our previous research on a new approach to automatic speech recognition (ASR) in the GSM environment. Instead of recognizing from the decoded speech signal, our system works from the digital speech representation used by the GSM encoder.
Valverde Albacete, Francisco José, Gallardo Antolín, Ascensión, F. Valverde-Albacete, F. Diaz-de-Maria, Díaz de María, Fernando, Díaz-de-María, Fernando, Valverde-Albacete, Francisco J., A. Gallardo-Antolin, Gallardo-Antolín, Ascensión   +8 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source