Results 71 to 80 of about 842,158 (297)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Laboratory PhonologyIn ongoing sound changes, a coarticulatory effect is often enhanced as the coarticulatory source that gives rise to it wanes. But quite how phonologisation and these reciprocal coarticulatory changes are connected is still poorly understood.
Jonathan Harrington +2 more
doaj +2 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Multimedia Quality as Perceived by the User
Communications, 2008 End-to-end voice quality as perceived by the user has always been of major concern to ETSI, the European Telecommunications Standards Institute and its Technical Committee STQ (Speech processing, Transmission and Quality aspects).
Jean-Yves Monfort +3 more
doaj +1 more source
FIT A Fog Computing Device for Speech TeleTreatments
, 2016 There is an increasing demand for smart fogcomputing gateways as the size of cloud data is growing. This paper presents a Fog computing interface (FIT) for processing clinical speech data.
Dubey, Harishchandra +4 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The effect of metacognitive strategy instruction on L2 learner beliefs and listening skills [PDF]
, 2016 This pilot study investigated the effect of semester-long strategy-based instruction on learner beliefs and skills in the processing of aural input by adult learners of English as a second language at metacognitive and procedural levels.
Harbaugh, Allen G. +2 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Adaptive Multi-Objective Optimization-Based Coverage Path Planning Method for UUVs
水下无人系统学报Coverage path planning for unmanned undersea vehicles(UUVs) in unknown aquatic environments is a critical task. However, due to environmental uncertainties, motion constraints, and energy limitations, traditional path planning methods struggle to adapt ...
Shaojing ZHAO +4 more
doaj +1 more source