Results 41 to 50 of about 118,715 (309)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Setting up the speech production network : how oscillations contribute to lateralized information routing

, 2012
Speech production involves widely distributed brain regions. This MEG study focuses on the spectro-temporal dynamics that contribute to the setup of this network. In 21 participants performing a cue-target reading paradigm, we analyzed local oscillations
Johannes Gehrig, Michael Wibral, Arnold, Christiane, Gehrig, Johannes, Christiane Arnold, Johannes eGehrig, Christian A Kell, Kell, Christian Alexander, Christiane eArnold, Michael eWibral, Christian A. Kell, Wibral, Michael   +11 more
core   +1 more source

Computer-Implemented Articulatory Models for Speech Production: A Review

Frontiers in Robotics and AI, 2022
Modeling speech production and speech articulation is still an evolving research topic. Some current core questions are: What is the underlying (neural) organization for controlling speech articulation?
Bernd J. Kröger
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Dysarthric speech classification using glottal features computed from non-words, words and sentences

, 2018
Dysarthria is a neuro-motor disorder resulting from the disruption of normal activity in speech production leading to slow, slurred and imprecise (low intelligible) speech.
Narendra N P, Paavo Alku, Alku, Paavo, Nonavinakere Prabhakera, Narendra   +3 more
core   +1 more source

Metaphorical maps as a means of developing speech imagery at classes of Russian as a foreign language

Russian Language Studies
The relevance of the study is conditioned by the need to develop speech imagery in foreigners studying Russian and to improve their communicative competence in speaking and writing.
Nina L. Fedotova, Alexandra V. Burtseva, Inna V. Ryzhkova   +2 more
doaj   +1 more source

Partially Overlapping Sensorimotor Networks Underlie Speech Praxis and Verbal Short-Term Memory: Evidence from Apraxia of Speech Following Acute Stroke

Frontiers in Human Neuroscience, 2014
We tested the hypothesis that motor planning and programming of speech articulation and verbal short-term memory (vSTM) depend on partially overlapping networks of neural regions. We evaluated this proposal by testing 76 individuals with acute ischemic
Gregory eHickok, Corianne eRogalsky, Rong eChen, Edward H. Herskovits, Sarah eTownsley, Argye eHillis, Argye eHillis   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Variability and Central Tendencies in Speech Production

Frontiers in Communication, 2019
Speech is notoriously variable, but our understanding of this variability continues to evolve. Variability has typically been taken as an indication of failure to reach a desired target due to physical or neurological limits.
D. H. Whalen, D. H. Whalen, D. H. Whalen, Wei-Rong Chen   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source