Results 101 to 110 of about 263,095 (308)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Comparison of plosive sounds in monolingual and bilingual children, using the voice onset time acoustic parameter: cases report

Revista CEFAC
The purpose was to compare differences in production of plosive phonemes through the voice onset time (VOT) measurement in the speech of monolingual children, speakers of Brazilian Portuguese and bilingual children, speakers of both Brazilian Portuguese ...
Maria Teresa R. Lofredo-Bonatto, Marta A. Andrada e Silva   +1 more
doaj   +1 more source

Acoustic emphasis in four year olds [PDF]

, 2008
Acoustic emphasis may convey a range of subtle discourse distinctions, yet little is known about how this complex ability develops in children. This paper presents a first investigation of the factors which influence the production of acoustic prominence
Ariel, Arnold, Avrutin, Brown, Campbell, Chafe, Dahan, Duane G. Watson, Elizabeth Wonnacott, Givon, Grosz, Gundel, Hickmann, Ladd, Prince, Snow, Song, Watson   +17 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Facial Movements Extracted from Video for the Kinematic Classification of Speech

Sensors
Speech Sound Disorders (SSDs) are prevalent communication problems in children that pose significant barriers to academic success and social participation. Accurate diagnosis is key to mitigating life-long impacts.
Richard Palmer, Roslyn Ward, Petra Helmholz, Geoffrey R. Strauss, Paul Davey, Neville Hennessey, Linda Orton, Aravind Namasivayam   +7 more
doaj   +1 more source

Características da fonetografia em coristas de diferentes classificações vocais Phonetography characteristics of choristers with different vocal classifications

Revista da Sociedade Brasileira de Fonoaudiologia, 2007
OBJETIVO: Caracterizar a dinâmica vocal por meio da fonetografia em coristas de diferentes classificações vocais. MÉTODOS: Participaram 44 indivíduos, de 19 a 75 anos (média=51,9 anos) membros de um coral profissional; sendo, oito sopranos, 20 mezzo ...
Thatiana Francisco de Camargo, Daniela Aparecida Barbosa, Lídia Cristina da Silva Teles   +2 more
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Duração do onset vocálico da fala fluente de gagos Voice onset duration of stutterers' fluent speech

Revista da Sociedade Brasileira de Fonoaudiologia, 2010
OBJETIVO: Comparar a duração da emissão da fala fluente de adultos com diferentes graus de gagueira em tarefa de repetição de frases. MÉTODOS: Seis adultos gagos, com grau de severidade variando de leve a severo, foram pareados com indivíduos sem nenhuma
Cláudia Fassin Arcuri, Ellen Osborn, Ana Maria Schiefer, Brasília Maria Chiari   +3 more
doaj   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source