Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Speaker adaptation and the evaluation of speaker similarity in the EMIME speech-to-speech translation project [PDF]
This paper provides an overview of speaker adaptation research carried out in the EMIME speech-to-speech translation (S2ST) project. We focus on how speaker adaptation transforms can be learned from speech in one language and applied to the acoustic ...
Tokuda, Keiichi +20 more
core +1 more source
Super-Wideband Spectral Envelope Modeling for Speech Coding
Significant improvements in the quality of speech coders have been achieved by widening the coded frequency range from narrowband to wideband. However, existing speech coders still employ a limited band source-filter model extended by parametric coding ...
Fuchs, Guillaume +5 more
core +1 more source
Facial Movements Extracted from Video for the Kinematic Classification of Speech
Speech Sound Disorders (SSDs) are prevalent communication problems in children that pose significant barriers to academic success and social participation. Accurate diagnosis is key to mitigating life-long impacts.
Richard Palmer +7 more
doaj +1 more source
OBJETIVO: Caracterizar a dinâmica vocal por meio da fonetografia em coristas de diferentes classificações vocais. MÉTODOS: Participaram 44 indivíduos, de 19 a 75 anos (média=51,9 anos) membros de um coral profissional; sendo, oito sopranos, 20 mezzo ...
Thatiana Francisco de Camargo +2 more
doaj +1 more source
Non-native listener perceptual similarity ratings as a measure of L2 speech production
This study investigates the feasibility of using non-native listeners to assess non-native pronunciation of different target languages. Native English-speaking students studying university-level German and French reproduced German, French, and Indonesian sentences based on native-speaker models. Students not pursuing university-level language study did
Carissa A. Diantoro, Melissa A. Redford
openaire +2 more sources
Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Sound Privacy: A Conversational Speech Corpus for Quantifying the Experience of Privacy
With the growing popularity of social networks, cloud services and online applications, people are becoming concerned about the way companies store their data and the ways in which the data can be applied.
Das, Sneha +9 more
core +1 more source
Duração do onset vocálico da fala fluente de gagos Voice onset duration of stutterers' fluent speech
OBJETIVO: Comparar a duração da emissão da fala fluente de adultos com diferentes graus de gagueira em tarefa de repetição de frases. MÉTODOS: Seis adultos gagos, com grau de severidade variando de leve a severo, foram pareados com indivíduos sem nenhuma
Cláudia Fassin Arcuri +3 more
doaj +1 more source

