Results 41 to 50 of about 50,727 (310)
Dimensional Affective Speech Synthesis Based on Voice Conversion
Intelligent ComputingAffective speech synthesis can promote more natural human–computer interaction. Previous studies in the field of speech synthesis have used feature conversion to achieve natural affective speech.
Xin Zhang, Yaobin Wan, Wei Wang
doaj +1 more source
Reducing over-smoothness in HMM-based speech synthesis using exemplar-based voice conversion
EURASIP Journal on Audio, Speech, and Music Processing, 2017 Speech synthesis has been applied in many kinds of practical applications. Currently, state-of-the-art speech synthesis uses statistical methods based on hidden Markov model (HMM).
Gia-Nhu Nguyen, Trung-Nghia Phung
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Multi Speaker Natural Speech Synthesis Using Generative Flows
Современные информационные технологии и IT-образование, 2021 Modern speech synthesis systems generate natural speech and have high performance. Models using generative flows, among others, have shown impressive results, allowing you to form a variety of speech pronunciation from a given text.
Dmitry Obukhov
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Emotional Speech Synthesis Method Based on PSOLA and DCT [PDF]
Jisuanji gongcheng, 2017 Emotional speech synthesis is expected to make the synthesized speech more expressive.In order to synthesis more natural emotional speech signals,this paper proposes a new emotional speech synthesis method combining Pitch Synchronous Overlap Add(PSOLA ...
LI Yong,WEI Dang,WANG Liuyu
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Robustness of HMM-based speech synthesis [PDF]
, 2008 As speech synthesis techniques become more advanced, we are able to consider building high-quality voices from data collected outside the usual highly-controlled recording studio environment.
Ling, Z. +5 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source