An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
When Weakness Persists Beyond Its Apparent Cause: A Case Report of Myasthenia Gravis. [PDF]
Ehsan N +4 more
europepmc +1 more source
Bioinspired Metastable Transient Peeling for Repeatable Rapid Release
Inspired by the explosive seed ejection of the squirting cucumber, this work introduces metastable transient peeling that temporally regulates stored interfacial energy release via a tunable energy barrier. A viscoelastic hemispherical gripper achieves 52 ms ultrafast, residue‐free release with 300 000‐cycle durability, enabling damage‐free handling of
Lvzhou Li +8 more
wiley +1 more source
Does Omega-3 Help After All in Autism Spectrum Disorder? An Update Systematic Review and Meta-Analysis of Randomized Trials. [PDF]
Sánchez-García I, Sánchez-Quesada C.
europepmc +1 more source
By exploiting multiscale hydrogen‐bonding interactions between HFPD and TOCNF, the composite simultaneously achieves a high piezoelectric coefficient (14.0 pC·N−1), outstanding flexibility (100 000 bending cycles), water‐assisted recyclability, excellent biodegradability, and sensitive wearable/implantable sensing for motion, speech, and Morse code ...
Tingshuai Luo +9 more
wiley +1 more source
Self-Powered MXene@Perovskite Thermoelectric Skin for Multimodal Mid-Infrared Sensing and Human Signal Recognition. [PDF]
Wang Q +9 more
europepmc +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Multilevel auditory and cognitive processing in post-stroke aphasia: associations with language performance using ABR, LLR, and P300: a cross-sectional observational study. [PDF]
Şimşek A, Ulutaş NS, Saman FD.
europepmc +1 more source
The multilayer fiber‐based PGC sensor, fabricated via graphene‐mediated electroless copper deposition, demonstrates high sensitivity, mechanical durability, and fast response speed. Additionally, it features low‐temperature thermal assisted recovery and thermal resistance, providing a promising platform for wearable electronic devices and IoT ...
ByungJun Kim +5 more
wiley +1 more source
What Is Old Is New Again: Tips and Tricks for Recognizing and Treating Vaccine-Preventable Diseases of Childhood Presenting to the Emergency Department. [PDF]
Seneviratne D, Semakula R.
europepmc +1 more source

