Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Temporal Auditory Resolution, Timed Motor Responses to Auditory Cues, and Phonological Processing in Swedish Children with Cochlear Implants and Normal Hearing Peers. [PDF]
Audiol ResLöwgren K, Sahlén B.
europepmc +1 more source
Advanced Science, EarlyView.Researchers developed and applied a generative artificial intelligence (AI) model to optimize epsilon‐near‐zero thin film stacks for ultra‐broadband perfect absorption of light. The fabricated AI‐designed absorber, with a total thickness of only 160 nm, experimentally demonstrated an absorption bandwidth exceeding 1000 nm while maintaining greater than
David Dang +10 more
wiley +1 more source
Spontaneous speech and language measures as predictive biomarkers of clinically meaningful disease progression and neurodegeneration in Huntington's disease. [PDF]
J Neural Transm (Vienna)Puig-Davi A +16 more
europepmc +1 more source
A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety
Advanced Science, EarlyView.Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao +8 more
wiley +1 more source
Advanced Science, EarlyView.Planar ferroelectric lattices with rationally‐tailored topology and polarization achieve programmable piezoelectric and pyroelectric properties. Analytical modeling, homogenization, and experiments collectively demonstrate enhanced and tunable longitudinal, transverse, and shear piezoelectric responses, together with substantially improved ...
Jiahao Shi +6 more
wiley +1 more source
Digital assessment in myasthenia gravis: evidence, validation, and a proposed framework for autoimmune heterogeneity, remote monitoring, and clinical endpoints. [PDF]
Front ImmunolWang M +5 more
europepmc +1 more source
Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems
Advanced Science, EarlyView.The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan +3 more
wiley +1 more source
Pretrained Financial Language Model-Guided Multimodal Sensing with Hardware Provenance and Cross-Frequency Temporal Alignment for Event Prediction. [PDF]
Sensors (Basel)Chen S +6 more
europepmc +1 more source