Results 81 to 90 of about 6,690,892 (354)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Effects of pretreatment methods on stability and abrasion performance of steel slag asphalt mixture

Frontiers in Materials
Steel slag presents a promising alternative to natural aggregates in asphalt pavements; however, its high free calcium oxide (f-CaO) content leads to volume instability, which limits its large-scale application.
Lemin Liu, Xufeng Wang, Weiliang Jiang, Weiliang Jiang, Guangyong Wang, Fuyong Zhang, Fuyong Zhang   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Computer programs and documentation [PDF]

Various statistical tests that were used to check out random number generators are described. A total of twelve different tests were considered, and from these, six were chosen to be used.
Broadwater, S. L., Speed, F. M.
core   +1 more source

Effects of the Reynolds Number on the Efficiency and Stall Mechanisms in a Three-stage Axial Compressor [PDF]

Journal of Applied Fluid Mechanics
The Reynolds number (Re) is an important parameter that can affect compressor performance. This study experimentally and numerically investigated the effect of Re variations on the efficiency and stall mechanisms for a three-stage axial flow compressor ...
E. Zhou, P. Lei, C. Fan, W. Zhang, K. Liu, S. Cheng   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

GENHYP - A FORTRAN 5 program for general linear hypothesis testing [PDF]

GENHYP FORTRAN 5 program for general linear hypothesis ...
Delaney, F. C., Speed, F. N.
core   +1 more source

Study on the Influence of Graphite Tailings on the Properties of Foamed Concrete

Advances in Civil Engineering
This article presents the application of untreated graphite tailings in foamed concrete by studying the properties of graphite tailings. It also investigates the effects of raw materials, water–cement ratio, and curing methods on the density, strength ...
Wenhao Zhang, Wenning Tang, Shaopeng Hu, Hao Xu, Guang Huo, Xiaoheng Sun, Jiandong Ge   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source