Results 81 to 90 of about 4,949 (262)

A Multibody Model Calibration Method for Vehicle Misuse Testing

Applied Sciences
This paper proposes a multibody model calibration method for vehicle misuse testing. During misuse tests conducted at high driving speeds, the vehicle’s responses can become highly nonlinear due to certain key model parameters. Direct calibration using a
Yuexin Wan, Cheng Yang, Xiaoyang Liu, Hao Dong, Lei Liang, Zhifeng Xie   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Speed Bump System Based on Vehicle Speed Using Adaptive Background Subtraction with Haar Cascade Classifier

Sistemasi: Jurnal Sistem Informasi
Driving at high speed and recklessly is the main cause of traffic accidents. In several places speed bumps are installed as a medium to warn drivers to slow down the speed of the vehicle, but the installation of speed bumps in several places has become a
Muhammad Zulfikri, Wirajaya Kusuma, Sirojul Hadi, Husain Husain, Rifqi Hammad, Lalu Zazuli Azhar Mardedi   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Affordable Road Obstacle Detection and Active Suspension Control Using Inertial and Motion Sensors

World Electric Vehicle Journal
The electrification trend characterizing the current automotive industry creates opportunities for the implementation of innovative functionalities, enhancing aspects of energy efficiency and vehicle dynamics.
Andrew Valdivieso-Soto, Gennaro Sorrentino, Giulia Moscone, Renato Galluzzi, Nicola Amati   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effects of Structure Parameters on Static Performance of Gas Foil Bearings Based on a New Fully Coupled Elastic–Aerodynamic Model

Lubricants
Accurately predicting the performance of gas foil bearings (GFBs) is important. This paper presents a new fully coupled elastic–aerodynamic model for analyzing the static performance of gas foil journal bearings (GFJBs).
Pengjing Ding, Yang Hu, Xiaojing Wang, Yonggang Meng   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Design and Test of an Energy-Saving Bionic-Inspired Rotary Blade: A Study on Power Consumption and Soil Surface Quality

Agriculture
To reduce the power consumption of rotary tillage and enhance the operational quality of rotary tillage, a rotary blade that imitates the surface of a pufferfish was designed through reverse engineering.
Yue Qin, Yunpeng Gao, Chenggong Xie, Jiarui Tong, Qi Wang, Xin Feng   +5 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source