Results 61 to 70 of about 1,217 (247)

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

Advanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She, Rui Liu, Chen Fang, Shuyu Zhang, Yizhi Hu, Fei Guo, Yuhang Long, Mengzhen Ding, Haiyan Wu, Bokang Zhou, Zexin Yang, Ying Jiang, Jianzhong Sheng, Ling Gao, Hefeng Huang   +14 more
wiley   +1 more source

Optimum design of speed control humps for vehicles.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1988
This paper deals with optimum design problems of humps for controlling vehicle speeds. Optimum humps are obtained for a segment of a circle in section using a method with a SUMT optimizing a hump for a vehicle. The objective of the design is to minimize the maximum acceleration of the driver occurring during a vehicle crossing a hump at a design speed ...
Ken'ichi MAEMORI, Katsuo SAKAMOTO
openaire   +2 more sources

The Effect of Speed Humps on Highways Pavement Condition [PDF]

International Journal of Engineering, 2020
Speed humps used as a tool of traffic calming technique that applied to force drivers to reduce their vehicle’ speeds at some locations. For developed countries, the implementations of speed humps are often used within residential areas as well as at locations of schools crossing.  For developing countries (e.g.
openaire   +1 more source

Evaluation of speed humps on pedestrian injuries in Ghana [PDF]

Injury Prevention, 2010
Objective To evaluate the effectiveness of speed humps in reducing pedestrian crashes at selected settlements located along the Konongo-Kumasi highway. Materials and Methods The study adopted before and after comparison of police reported casualty ...
F K Afukaar, J Damsere-Derry
openaire   +1 more source

Prevalence of illegal speed humps on Ghana’s rural highways and their implication for road safety: a case study of selected trunk roads in Ghana

Discover Civil Engineering
In Ghana, unauthorized speed humps are increasingly appearing on many main roads that run through rural communities, highlighting the residents’ concerns about the dangers of speeding traffic.
Kwadwo Appiah Boateng, Joshua J. Vordoagu, Stephen Agyeman, Collins Nyaaba, Therdius Boateng   +4 more
doaj   +1 more source

Capture and Culture of Circulating Tumor Cells Using a Biodegradable 3D Scaffold for Patient‐Derived Xenograft Construction

Advanced Science, EarlyView.
A self‐supporting, biocompatible, and biodegradable 3D cellulose scaffold has been developed for efficient isolation and in situ expansion of circulating tumor cells (CTCs) from patient blood. Subsequently, the 3D cellulose scaffold with cultured CTCs is directly implanted into immunodeficient mice for constructing patient CTC‐derived xenograft (CDX ...
Yi‐Ke Wang, Ming Wang, Min Liu, Yi‐Jing Chen, Li‐Li Xu, Jin‐Ping Zhou, Fu‐Bing Wang, Shi‐Bo Cheng, Min Xie, Wei‐Hua Huang   +9 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

A METHOD OF COMPLEX CALCULATION OF RATIONAL STRUCTURAL PARAMETERS OF RAILWAY HUMPS

Acta Polytechnica, 2018
The article deals with a method of complex calculation of rational structural parameters of humps at classification yards. Unlike existing methods, this method allows an implementation of the technology of guided gravity regulation of the cut speed by ...
Sergii Panchenko, Oleksandr Ohar, Maksym Kutsenko, Julia Smachilo   +3 more
doaj   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Photon‐Sphere Modes in Curved Optical Microcavities: A Black‐Hole Analogue Laser

Advanced Science, EarlyView.
An optical analogue of a Schwarzschild black hole is realized using curved microcavities that preserve light‐like geodesics. A new family of laser modes confined around the photon sphere is identified alongside conventional whispering‐gallery modes. Analytical theory, numerical simulations, and experiments reveal curvature‐induced confinement, enabling
Chenni Xu, Aswathy Sundaresan, Nazire‐Begüm Kazkal, Clement Lafargue, Lior Zarfaty, Li‐Gang Wang, Ofek Birnholtz, Dominique Decanini, Melanie Lebental, Patrick Sebbah   +9 more
wiley   +1 more source