Results 61 to 70 of about 1,150,719 (355)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Financial Regulation and the Speed of Financial Risks
Œconomia, 2017 This paper argues that the speed of financial risks, rather than the speed of regulators, is the key cause of financial crises. Our argument contradicts a common claim in the literature that financial crises arise because regulators cannot keep up with ...
Ralph Chami +3 more
doaj +1 more source
EyeSpot: leveraging gaze to protect private text content on mobile devices from shoulder surfing [PDF]
, 2018 As mobile devices allow access to an increasing amount of private data, using them in public can potentially leak sensitive information through shoulder surfing.
Eiband, Malin +3 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
SUSTAINABILITY ASSESSMENT OF SPEED REGULATION OF URBAN TRAFFIC
IATSS Research, 2002 Speed regulation of motor vehicles has widely affected the living environment and standard of residents in urban areas. It is believed that lower speed of motor vehicles could decrease the traffic accident rate on roads.
Baohua MAO, Ph.D.
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
LubricantsTo meet the requirements of in-pipeline inspection tasks, this paper designs a fluid-driven pipeline magnetic flux leakage (MFL) inspection robot with controllable speed.
Haichao Liu +4 more
doaj +1 more source
Front Cover: Reversible Speed Regulation of Self‐Propelled Janus Micromotors via Thermoresponsive Bottle‐Brush Polymers (Chem. Eur. J. 10/2021) [PDF]
, 2021 Christine Fiedler +8 more
openalex +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source