Results 51 to 60 of about 267,539 (298)

Gatekeepers of the Germ Line: How Mitochondria Shape Reproductive Evolution in Metazoans

Biology
Mitochondria play essential roles for animal reproduction, influencing not only cellular energetics but also gamete quality, inheritance and evolutionary patterns.
Yu-Tong Sun, Wan-Xi Yang
doaj   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Does the FNA sperm retrieval failure prediction model work well for current NOA individuals undertaking risk screening before the operation? Model validation, high-risk population identification and potential alternative sperm retrieval exploration

BMC Medical Informatics and Decision Making
Background Non-obstructive azoospermia (NOA), the severe type of male infertility. The objective of this study was to evaluate the predictive accuracy of a prediction model of sperm retrieval failure with fine needle aspiration (FNA).
Xiaohui Jiang, Dingming Li, Yi Zheng, Yinxian Li, Hengzhou Bai, Guicheng Zhao, Yi Zhang, Yue Ma   +7 more
doaj   +1 more source

Nematode sperm

Parasitology Today, 1996
Parasitic nematode infections remain a major public health problem in many parts of the world. Because most of the current strategies aimed at controlling parasitic nematode infections have met with only limited success, it may be time to consider alternative approaches.
openaire   +2 more sources

Sperm Viability and Sperm Competition in Insects [PDF]

Current Biology, 2002
Sperm quality plays an important role in vertebrates in determining which male has the advantage when two or more males compete to fertilize a female's ova. In insects, however, the importance of sperm quality has never been considered, despite sperm competition being widespread and well studied in this group.
Hunter, F.M, Birkhead, T.R
openaire   +2 more sources

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Cryopreservation Does Not Affect the Clinical Pregnancy Rate of Blastocysts Derived from Vitrified Oocytes

Scientific Reports, 2022
Vitrified, or “frozen”, donor eggs can either be fertilized and cultured for fresh transfer (group 1), or fertilized and cryopreserved for transfer in a “frozen embryo transfer” cycle (group 2).
Hadi Ramadan, Tarita Pakrashi, Andrea R. Thurman, Kimball O. Pomeroy, Gerard Celia   +4 more
doaj   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Integrated profiling of semen microbiota and metabolome reveals dysregulation in primary idiopathic male infertility

Journal of Translational Medicine
Background Primary idiopathic male infertility remains a significant challenge due to its complex etiology and the lack of effective diagnostic tools.
Hailin Yao, Chen Luo, Yang Xian, Bo Liu, Tingting Yang, Run Tian, Xiao Xiao, Wenrui Zhao, Lijuan Ying, Jinyan Xu, Shasha Liu, Yelin Jia, Xuefeng Luo, Dajian Qiu, Yuan Liu, Qinqin Wu, Xiaohong Luo, Zhenmi Liu, Fuping Li   +18 more
doaj   +1 more source

Obstetric and perinatal outcomes in pregnancies conceived with donor versus partner sperm: a systematic review and meta-analysis

Frontiers in Endocrinology
BackgroundMale-related factors contribute to 30-40% of infertility cases, with donor sperm serving as a critical solution for severe male infertility or paternally inherited genetic disorders.
Junjie Liu, Yanpeng Dai, Zuozhe Song, Xintao Sun, Dongdong Lv, Dehua Zhao   +5 more
doaj   +1 more source