Results 71 to 80 of about 552,185 (343)

Recommendations for the Use of Disease‐Modifying Antirheumatic Drugs in Pregnancy and Reproductive Health for Patients With Rheumatic Disease: A Scoping Review

Arthritis Care &Research, EarlyView.
Objective Autoimmune rheumatic diseases commonly affect individuals of childbearing age, with historically increased adverse pregnancy outcomes in this group. The advent of disease‐modifying antirheumatic drugs (DMARDs) has fostered more suitable conditions for pregnancy; however, this is accompanied by challenges in ensuring safe use in reproductive ...
Athena Chin, Alice Terrett, Mihye Kwon, Samuel Whittle, Catherine Hill   +4 more
wiley   +1 more source

Larger testes are associated with a higher level of polyandry, but a smaller ejaculate volume, across bushcricket species (Tettigoniidae) [PDF]

, 2010
While early models of ejaculate allocation predicted that both relative testes and ejaculate size should increase with sperm competition intensity across species, recent models predict that ejaculate size may actually decrease as testes size and sperm ...
Darren J. Parker, James D. J. Gilbert, Karim Vahed, Simmons L. W.   +3 more
core   +3 more sources

Double‐Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi‐Mediated Gene Silencing in Halyomorpha halys

Advanced Biology, EarlyView.
The invasive pest Halyomorpha halys causes significant crop losses requiring innovative pest control strategies such as RNA interference (RNAi). However, oral RNAi is largely ineffective in H. halys. This study shows that double‐stranded DNA (dsDNA) stabilizes dsRNA in saliva by inhibiting a highly expressed nuclease.
Venkata Partha Sarathi Amineni, Georg Petschenka, Aline Koch   +2 more
wiley   +1 more source

Sperm allocation strategies in a sperm heteromorphic insect [PDF]

Current Zoology, 2019
AbstractTheories predict that in polyandrous species, the focal male should increase sperm allocation per mate in the presence of rivals to gain greater share of paternity, but in the presence of additional mates, he should reduce sperm allocation per mate to save sperm for insemination of more mates.
Xiong Zhao He, Kambiz Esfandi, Kambiz Esfandi, Qiao Wang   +3 more
openaire   +3 more sources

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Cryopreservation Does Not Affect the Clinical Pregnancy Rate of Blastocysts Derived from Vitrified Oocytes

Scientific Reports, 2022
Vitrified, or “frozen”, donor eggs can either be fertilized and cultured for fresh transfer (group 1), or fertilized and cryopreserved for transfer in a “frozen embryo transfer” cycle (group 2).
Hadi Ramadan, Tarita Pakrashi, Andrea R. Thurman, Kimball O. Pomeroy, Gerard Celia   +4 more
doaj   +1 more source

Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway

Ecotoxicology and Environmental Safety, 2023
As a common pollutant in the water environment, microcystin leucine arginine (MC-LR) can enter semen and damage the sperm in animals. However, the mechanism by which MC-LR damages human sperm is unclear.
Xing Guo, Ruiyang Meng, Junjie Liu, Shiyu Zhang, Haohao Liu, Xingde Du, Huizhen Zhang, Yushan Li   +7 more
doaj   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Sperm chromatin dispersion test before sperm preparation is predictive of clinical pregnancy in cases of unexplained infertility treated with intrauterine insemination and induction with clomiphene citrate [PDF]

, 2016
Background/aims: A large proportion of men with normal sperm results as analyzed using conventional techniques have fragmented DNA in their spermatozoa.
De Croo, Ilse, De Sutter, Petra, Gerris, Jan, Van den Abbeel, Etienne, Vandekerckhove, Frank   +4 more
core   +2 more sources

Obstetric and perinatal outcomes in pregnancies conceived with donor versus partner sperm: a systematic review and meta-analysis

Frontiers in Endocrinology
BackgroundMale-related factors contribute to 30-40% of infertility cases, with donor sperm serving as a critical solution for severe male infertility or paternally inherited genetic disorders.
Junjie Liu, Yanpeng Dai, Zuozhe Song, Xintao Sun, Dongdong Lv, Dehua Zhao   +5 more
doaj   +1 more source