Results 71 to 80 of about 109,348 (344)

CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions

open access: yesAdvanced Science, EarlyView.
CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng   +27 more
wiley   +1 more source

Decline in human sperm counts during the past 50 years? [PDF]

open access: yes, 2005
There is widespread concern that environmental pollutants acting as xenoestrogens may affect human fertility adversely. Whether this has already made an impact on human fertility worldwide remains debatable at the present stage.
Jayachandra, Srinivasa   +2 more
core  

Nurr1 Orchestrates Claustrum Development and Functionality

open access: yesAdvanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan   +12 more
wiley   +1 more source

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat II: chronic dosing causes developmental delay [PDF]

open access: yes, 2007
We have investigated whether fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat, using chronically exposed rats to ensure continuous exposure of the fetus. 5-6 week old rats were exposed
Bell, David Robert   +11 more
core   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

open access: yesAdvanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang   +9 more
wiley   +1 more source

Risultati del trattamento chirurgico del varicocele nella infertilità maschile [PDF]

open access: yes, 2005
To evaluate the results of surgical treatment of varicocele on infertile men, especially regarding sperm count, 245 patients, surgically treated from 1993 to 2003, were evaluated.
Borghese, Mario   +4 more
core  

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

open access: yesAdvanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang   +10 more
wiley   +1 more source

Is semen analysis without strict criteria misleading decisions in IVF? A prospective systematic study

open access: yesInternational Journal of Reproductive BioMedicine, 2018
Background: Sperm morphology has been strongly linked to fertilization. This makes it an important component in semen analysis. They are usually assessed by world health organization (WHO) standard or Kruger strict criteria in in-vitro fertilization (IVF)
Faduola Paul   +2 more
doaj  

Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats

open access: yesThe World Journal of Men's Health, 2019
Purpose: To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. Materials and Methods: Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone ...
Cem Yucel   +10 more
doaj   +1 more source

Effects of cryopreservation on performance and fertilizing ability of sperm from Kerai (Puntius daruphani) [PDF]

open access: yes, 2008
Puntius daruphani broodstocks bought from fishermen in Temerloh, Pahang, conditioned in the Hatchery Unit of Universiti Putra Malaysia were used for all the experiments. In this study fresh and cryopreserved sperm of P.
Emhemed, Mohamed M. M.
core  

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