Results 51 to 60 of about 1,138,325 (289)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

The effects of cinnamon consumption on sperm count, concentration, morphology, and motility: A systematic review [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Some of the causes of male infertility are sperm disorders including changes in sperm concentration, viability, motility, and morphology. Historically, traditional remedies like cinnamon bark have been utilized for treating fertility issues.
Aref Adeli Mosabbeb, Ghazaleh Eslamian, Negin Majdi   +2 more
doaj   +1 more source

Effect of Breadfruit Leaf Extract on Sperm Quality in Diabetic Male Wistar Rats

Jurnal Kedokteran Diponegoro, 2023
Background: Diabetes mellitus can lead to various complications, one of the most devastating complications is infertility. Meanwhile, the antioxidant compounds of breadfruit leaves have been shown to help heal oxidative stress and therefore prevent ...
Rafi Ilmansyah, Ulya Hasna Khairunnisa, Cendikia Sengkalaning Pangrukti, Rifki Rizaldi, Rr Mahayu Dewi Ariani, Donna Hermawati, Eka Chandra Herlina, Acmad Zulfa Juniarto   +7 more
doaj   +1 more source

Effects of Normal Morphology Sperm Count on Fertilization Time in Infertile Couples with Teratospermic Males: An Evaluation with an Embryoscope

, 2022
Objective:Incubation of the embryo is the vital step in assisted reproductive techniques. Embryoscope systems are incubators that keep the embryo stable and allow for continuous observation without opening the lid.
Karabuk, Emine, Emine Karabük, Elif Ganime Aygun, Aygun, Elif Ganime   +3 more
core   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

The morphological normalcy of the sperm nucleus and pregnancy rate of intracytoplasmic injection with morphologically selected sperm [PDF]

Human Reproduction, 2005
Our preceding studies have already demonstrated the advantage of intracytoplasmic morphologically selected sperm injection (IMSI) over the conventional IVF-ICSI procedure in terms of pregnancy rate. This study was undertaken to determine whether the increased pregnancy outcome was attributable to the preferred nuclear morphology of the selected ...
Arie, Berkovitz, Fina, Eltes, Shlomit, Yaari, Nathan, Katz, Ilya, Barr, Ami, Fishman, Benjamin, Bartoov   +6 more
openaire   +2 more sources

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Our experience in sperm morphology assessment [PDF]

Asian Journal of Andrology, 2010
We read with great interest the article recently published by Menkeveld et al.1 as we have a double interest in sperm morphology assessment. The first one as a Clinical Andrology Laboratory (Laboratory of Male Fertility, Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) attempting to give ...
Julia Irene, Ariagno, Susana Mercedes, Curi, Patricia, Chenlo, Herberto Ernesto Hector, Repetto, Mercedes Norma, Pugliese, Luis Alberto, Palaoro, Melba, Sardi, Gabriela Ruth, Mendeluk   +7 more
openaire   +2 more sources

Sperm collection in Black-legged Kittiwakes and characterization of sperm velocity and morphology

Avian Research, 2018
Background Collecting and studying live sperm is central to many important fields of biology. Yet, a simple method to collect live sperm is lacking in wild seabird species.
Ségolène Humann-Guilleminot, Pierre Blévin, Antonin Azou-Barré, Agathe Yacoumas, Geir Wing Gabrielsen, Olivier Chastel, Fabrice Helfenstein   +6 more
doaj   +1 more source