Results 41 to 50 of about 55,911 (260)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Serum lipid profiles are associated with semen quality

Asian Journal of Andrology, 2017
We aimed to explore the associations between different lipid profiles and semen quality in a large-scale general male population. Sperm concentration, total sperm motility, progressive motility, and normal sperm morphology of total 7601 participants were
Chin-Yu Liu, Yu-Ching Chou, Shyh-Hsiang Lin, Sheng-Tang Wu, Tai-Lung Cha, Hong-I Chen, Chih-Wei Tsao   +6 more
doaj   +1 more source

Apical Sperm Hook Morphology Is Linked to Sperm Swimming Performance and Sperm Aggregation in Peromyscus Mice

Cells, 2021
Mammals exhibit a tremendous amount of variation in sperm morphology and despite the acknowledgement of sperm structural diversity across taxa, its functional significance remains poorly understood. Of particular interest is the sperm of rodents.
Kristin A. Hook, Lauren M. Wilke, Heidi S. Fisher   +2 more
doaj   +1 more source

Our experience in sperm morphology assessment [PDF]

Asian Journal of Andrology, 2010
We read with great interest the article recently published by Menkeveld et al.1 as we have a double interest in sperm morphology assessment. The first one as a Clinical Andrology Laboratory (Laboratory of Male Fertility, Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) attempting to give ...
Julia Irene, Ariagno, Susana Mercedes, Curi, Patricia, Chenlo, Herberto Ernesto Hector, Repetto, Mercedes Norma, Pugliese, Luis Alberto, Palaoro, Melba, Sardi, Gabriela Ruth, Mendeluk   +7 more
openaire   +2 more sources

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Sperm collection in Black-legged Kittiwakes and characterization of sperm velocity and morphology

Avian Research, 2018
Background Collecting and studying live sperm is central to many important fields of biology. Yet, a simple method to collect live sperm is lacking in wild seabird species.
Ségolène Humann-Guilleminot, Pierre Blévin, Antonin Azou-Barré, Agathe Yacoumas, Geir Wing Gabrielsen, Olivier Chastel, Fabrice Helfenstein   +6 more
doaj   +1 more source

Decline of Sperm Quality over the Last Two Decades in the South of Europe: A Retrospective Study in Infertile Patients

Biology, 2022
Semen quality has a direct relation to male fertility. Whether sperm variables in humans have decreased over the last years is still uncertain, with some studies showing a decline and others reporting no changes.
Emma Garcia-Grau, Judith Lleberia, Laura Costa, Miriam Guitart, Marc Yeste, Jordi Benet, María José Amengual, Jordi Ribas-Maynou   +7 more
doaj   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

The role of sperm morphology in assisted reproduction [PDF]

Human Reproduction Update, 1999
This article attempts to evaluate the value of sperm morphology in assisted reproduction by summarizing a recent structured literature review covering the topic. New developments in the field of sperm morphology with emphasis on computer evaluation of morphology and its latest clinical application are highlighted, as well as the correlation between ...
T F, Kruger, K, Coetzee
openaire   +2 more sources

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source