The impact of fresh versus cryopreserved testicular sperm on in-vitro fertilization outcomes in couples with elevated sperm DNA fragmentation: a retrospective cohort study. [PDF]
Siegel DR +3 more
europepmc +1 more source
Evaluating Reproductive Health Recommendations in CPGs for Sickle Cell Disease: An Umbrella Review
ABSTRACT Background Individuals with sickle cell disease or trait (SCD/T) face significant reproductive health risks, highlighting the need to assess the best available evidence on their reproductive health needs. Objectives To assess the quality of SCD/T clinical practice guidelines and evaluate the key characteristics and quality of their ...
Lisa R. Roberts +4 more
wiley +1 more source
Potentially toxic elements impair male reproductive function through oxidative stress, DNA damage, mitochondrial dysfunction, inflammation, endocrine disruption and epigenetic alterations. Antioxidants, phytochemicals, chelating agents and healthy lifestyle interventions may help mitigate testicular toxicity and preserve fertility.
Sakshi Yadav, Placheril J John
wiley +1 more source
Association of paternal age with embryological outcomes and β-hCG positivity in women with polycystic ovary syndrome undergoing ICSI: a retrospective cohort study. [PDF]
Şahin F +5 more
europepmc +1 more source
Production of indigoidine (IND) increased from 1.04 to 2.76 g/L using an optimized LB medium composed of glucose, l‐glutamine, tryptone, yeast extract, MgSO4·7H2O, and KH2PO4. The IND has significant inhibition properties against amylase and lipase enzymes, stimulates AMPK and AKT pathways, and improves glucose uptake.
Tahani Ali Asseri
wiley +1 more source
Diffuse testicular microlithiasis is associated with successful sperm retrieval in men with nonobstructive azoospermia. [PDF]
Tsuji Y +4 more
europepmc +1 more source
ABSTRACT The aim of this study was to characterize the proteome of sperm and seminal plasma (SP) from rams with high semen freezability (HF) and low semen freezability (LF). Eleven ejaculates were collected from 12 rams, at 3‐day intervals, and cryopreserved (132 semen samples).
Wallisson Bruno de Morais Pacheco +14 more
wiley +1 more source
Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging
We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang +12 more
wiley +1 more source
Intraoperative epididymal sperm cryopreservation during microsurgical vasoepididymostomy for obstructive azoospermia: intracytoplasmic sperm injection outcomes from a single-center cohort. [PDF]
Gao J +11 more
europepmc +1 more source
DNMT1 Regulates Testosterone Synthesis in Aged Rat Leydig Cells via FTO‐Mediated HSP90AA1 m6A Levels
During Leydig cell senescence, decreased DNMT1 triggers Fto promoter hypomethylation and upregulates FTO. Elevated FTO reduces m6A modification of Hsp90aa1, lowering HSP90AA1 to inhibit AKT signaling, facilitate apoptosis and reduce testosterone synthesis.
Yaqi Li +8 more
wiley +1 more source

