Results 81 to 90 of about 65,346 (303)

Pitfalls in experiments testing predictions from sperm competition theory

, 2005
Engqvist L, Reinhold K. Pitfalls in experiments testing predictions from sperm competition theory. Journal of Evolutionary Biology. 2005;18(1):116-123.As females of many species mate with more than one male, ejaculates often face competition from the ...
Reinhold, Klaus, L. Engqvist, K. Reinhold, Engqvist, Leif ; https://orcid.org/   +3 more
core   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Selection Bias in Occupational Sperm Studies [PDF]

American Journal of Epidemiology, 1998
Participation rates in sperm studies are typically 25-50%, and therefore it is a matter of concern whether the men who provide semen samples truly reflect the parent population. The authors analyzed data from three Danish occupational sperm studies and evaluated the relation between age and occurrence of subfertility to participation and provision of ...
S B, Larsen, A, Abell, J P, Bonde
openaire   +2 more sources

Testes size, testosterone production and reproductive behaviour in a natural mammalian mating system [PDF]

, 2011
1. Testosterone (T) is a key mediator in the expression of numerous morphological and behavioural traits in mammals, but the factors underlying individual variation in circulating T levels are poorly understood. 2.
Monfort, Steven L., Stevenson, Ian R., Brian T. Preston, Gerald A. Lincoln, Preston, Brian T., Steven L. Monfort, Lincoln, Gerald A., Kenneth Wilson, Pilkington, Jill G., Wilson, Kenneth, Ian R. Stevenson, Jill G. Pilkington   +11 more
core   +1 more source

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers

Advanced Science, EarlyView.
Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang, Chong Wang, Mengqi Han, Yi Yang, Teng Ma, Luoran Shang   +5 more
wiley   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Deep learning-based selection of human sperm with high DNA integrity

, 2019
Despite the importance of sperm DNA to human reproduction, currently no method exists to assess individual sperm DNA quality prior to clinical selection.
Sanner, Scott, Lagunov, Alexander, Jarvi, Keith (6801734), Christopher McCallum (6106760), Jason Riordon (1354509), Sinton, David (6801737), Yihe Wang (1554496), Riordon, Jason, Wang, Yihe, Riordon, Jason (6801713), Sinton, David, Keith Jarvi (6697615), Jae Bem You (1603612), Hannam, Thomas G (6801731), McCallum, Christopher, McCallum, Christopher (6801710), Wang, Yihe (6801716), Jarvi, Keith, Kong, Tian, Sanner, Scott (6801725), Tian Kong (6697607), Scott Sanner (5510303), Hannam, Thomas G, You, Jae Bem (6801722), You, Jae Bem, Kong, Tian (6801719), Thomas Hannam (6697614), Lagunov, Alexander (6801728), David Sinton (1280736), Alexander Lagunov (6697611)   +29 more
core   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Protein-carbohydrate interactions during fertilization [PDF]

, 1998
Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Plendl, J., Sinowatz, Fred, Kolle, S.
core   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source