Results 251 to 260 of about 168,606 (377)

CircCDYL Association With hnRNPL Modulates CDYL Isoform Switching in Breast Cancer Cells

open access: yesCancer Science, EarlyView.
We investigated the synergic role of the circRNA circCDYL and the splicing factor hnRNPL in modulating alternative splicing and isoform switch in breast cancer cells, with a focus on circCDYL and hnRNPL‐mediated isoform switch events involving the CDYL gene.
Serena Bernardi   +11 more
wiley   +1 more source

Testicular Function After Immune‐Checkpoint Inhibitors Treatment

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective To investigate the effects of immune‐checkpoint inhibitors (ICIs) on spermatogenesis and testicular endocrine function in reproductive‐age men with melanoma. Design Prospective, mixed longitudinal and cross‐sectional cohort study. Patients Twenty‐nine men aged 19–46 years undergoing ICI therapy for melanoma at two Australian centres ...
Andrea Boutros   +8 more
wiley   +1 more source

RNF187 Facilitates Proliferation and Migration of Human Spermatogonial Stem Cells Through WDR77 Polyubiquitination

open access: yesCell Proliferation, EarlyView.
RNF187 mediates the polyubiquitination and subsequent degradation of WDR77, reduces H4R3me2s catalysed by the WDR77/PRMT5 complex, and derepresses the transcription of EGR1, thereby promoting the proliferation and migration of human SSCs. ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING ...
Haoyue Hu   +12 more
wiley   +1 more source

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