Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility
Reproductive Biology and Endocrinology, 2020 Background Long non-coding RNAs (lncRNAs) have a size of more than 200 bp and are known to regulate a host of crucial cellular processes like proliferation, differentiation and apoptosis by regulating gene expression.
Meghali Joshi, S. Rajender
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In Vitro Spermatogenesis in Explanted Adult Mouse Testis Tissues. [PDF]
PLoS ONE, 2015 Research on in vitro spermatogenesis is important for elucidating the spermatogenic mechanism. We previously developed an organ culture method which can support spermatogenesis from spermatogonial stem cells up to sperm formation using immature mouse ...
Takuya Sato +5 more
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Frontiers in Veterinary Science, 2021 Mammalian spermatogenesis is a highly ordered process that is determined by chromatin-associated moderators which still remain poorly understood. Through a multi-control group proteomics strategy, we confirmed that Sugp2 was a chromatin-associated ...
Junfeng Zhan +22 more
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An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation [PDF]
, 2017 Global transcriptome reprogramming during sper-matogenesis ensures timely expression of factors in each phase of male germ cell differentiation. Sper-matocytes and spermatids require particularly exten-sive reprogramming of gene expression to switch from
Alberdi, Antonio J. +9 more
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Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. [PDF]
, 2020 Male factor infertility is a problem in today's society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model ...
Behr, Rüdiger +10 more
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In vivo functions of miRNAs in mammalian spermatogenesis
Frontiers in Cell and Developmental Biology, 2023 MicroRNAs (miRNAs) are believed to play important roles in mammalian spermatogenesis mainly because spermatogenesis is more or less disrupted when genes encoding key enzymes for miRNA biogenesis are mutated.
Jian Chen +6 more
doaj +1 more source
Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]
, 2010 Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H. +4 more
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Spermatogenesis: The Commitment to Meiosis.
Physiological Reviews, 2016 Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell numbers, the completion of reduction division to haploid cells (meiosis), and the morphological transformation of the haploid cells into spermatozoa (spermiogenesis ...
M. Griswold
semanticscholar +1 more source
Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]
, 2009 Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H. +4 more
core +1 more source
Spermatogenesis in the boar [PDF]
Veterinary Quarterly, 1982 In order to study kinetics of the spermatogenic epithelium in the adult boar, a method has been developed to prepare seminiferous tubules mounted as a whole, after which these tubules have been processed and studied as described previously only for rats, mice and hamsters.
M. T. Frankenhuis +2 more
openaire +2 more sources