Results 51 to 60 of about 58,630 (199)
Semen cryopreservation and storage in liquid nitrogen: Impact on chromatin compaction
Abstract Background Sperm cryopreservation is a consolidate option for long‐term male fertility preservation. The freezing/thawing procedure causes detrimental effects to spermatozoa, including damage to viability, motility, membrane composition, and DNA, whereas the effect on sperm chromatin compaction is less studied.
Lara Tamburrino+8 more
wiley +1 more source
Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice
Abstract Background Inhibition of sperm maturation in the epididymis is a promising post‐testicular strategy for short‐acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice.
Yuki Oyama+9 more
wiley +1 more source
Abstract Background Current advances in high‐throughput sequencing technology enable the precise identification of Y chromosome microdeletion and primary duplication in infertile couples, but the mechanism and clinical significance of these mutations in assisted reproductive techniques remain unclear.
Linlin Li+4 more
wiley +1 more source
HYPOANDROGENIC SYNDROME WITH NORMAL SPERMATOGENESIS [PDF]
R Q Pasqualini
openalex +1 more source
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin+11 more
wiley +1 more source
Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi+5 more
wiley +1 more source
Update on andrological effects of SARS‐CoV‐2 infection and COVID‐19: An overview review
Abstract Background Evidence indicates a wide range of andrological alterations in patients with the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS‐CoV‐2) infection and Coronavirus Disease 2019 (COVID‐19). Aim To provide an update on the andrological effects of SARS‐CoV‐2 infection and COVID‐19.
Giuseppe Lisco+7 more
wiley +1 more source
Abstract Background and objectives Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in testis and sperm. We showed that GSK3α is essential for epididymal sperm maturation and fertilization.
Mustfa Kabi+5 more
wiley +1 more source