Results 51 to 60 of about 102,741 (261)
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis
Cell Death and Disease, 2019 The functions of Sertoli cells in spermatogenesis have attracted much more attention recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on nutrient supply, maintenance of cell junctions, and support for germ cells ...
Fei-da Ni, Shuang-li Hao, Wan-Xi Yang
semanticscholar +1 more source
Dissecting mammalian spermatogenesis using spatial transcriptomics
bioRxiv, 2020 Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs governing mammalian spermatogenesis but fails to delineate their dynamics in the native context of seminiferous tubules — the spatially-confined functional units of ...
Haiqi Chen +12 more
semanticscholar +1 more source
Understanding spermatogenesis is a prerequisite for treatment
Reproductive Biology and Endocrinology, 2003 Throughout spermatogenesis multiplication, maturation and differentiation of germ cells results in the formation of the male gamete. The understanding of spermatogenesis needs detailed informations about the organization of the germinal epithelium, the ...
Schulze Wolfgang +2 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2021 Background Infertility is a common complication in obese men. Oxidative stress and testicular apoptosis play critical roles in obesity-induced spermatogenesis dysfunction.
Yang Mu +3 more
doaj +1 more source
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, EarlyView.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate
eLife, 2021 Exposure to environmental factors during fetal development may lead to epigenomic modifications in fetal germ cells, altering gene expression and promoting diseases in successive generations.
Yukiko Tando +5 more
doaj +1 more source
Advanced Science, EarlyView.This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li +11 more
wiley +1 more source
SRSF2 is required for mRNA splicing during spermatogenesis
BMC Biology, 2023 Background RNA splicing plays significant roles in fundamental biological activities. However, our knowledge about the roles of alternative splicing and underlying mechanisms during spermatogenesis is limited. Results Here, we report that Serine/arginine-
Wen-Long Lei +17 more
doaj +1 more source
Effects of dioxins on animal spermatogenesis: A state-of-the-art review
Frontiers in Reproductive Health, 2022 The male reproductive system is especially affected by dioxins, a group of persistent environmental pollutants, resulting in irreversible abnormalities including effects on sexual function and fertility in adult males and possibly on the development of ...
Walaa Faiad +3 more
doaj +1 more source