Results 81 to 90 of about 102,741 (261)

Kinesins in spermatogenesis† [PDF]

Biology of Reproduction, 2017
Kinesins are essential for the proper function of many types of polar cells, including epithelial cells, neurons, and sperm. Spermatogenesis is closely associated with many different kinesins. These kinesins participate in several fundamental processes, including mitotic and meiotic division, essential organelle transport, and the biogenesis of ...
Dan-Dan, Ma, Da-Hui, Wang, Wan-Xi, Yang
openaire   +2 more sources

SPARK: A webserver for comprehensive search and analysis of testicular single‐cell transcriptomic data covering full lifecycle and pathology

iMetaOmics, EarlyView.
SPARK is an interactive platform hosting 189,232 human testicular single‐cell transcriptomes across normal and infertile conditions. It enables automated, code‐free analysis and visualization, providing a powerful resource to explore cellular and molecular dynamics in male reproduction and infertility.
Lina Cui, Xiaojian Lu, Hui Cai, Ziyan Zhuang, Yifei Guo, Qiaoling Jiang, Zhe Zhang, Hui Jiang, Xiaoyan Wang, Jingtao Guo   +9 more
wiley   +1 more source

Role of Follicle-Stimulating Hormone in Spermatogenesis

Frontiers in Endocrinology, 2018
Spermatogenesis is a concerted sequence of events during maturation of spermatogonia into spermatozoa. The process involves differential gene-expression and cell-cell interplay regulated by the key endocrine stimuli, i.e., follicle-stimulating hormone ...
O. Oduwole, H. Peltoketo, I. Huhtaniemi
semanticscholar   +1 more source

Single Cell Map of Human Azoospermia Testis Caused by Cyclophosphamide Chemotherapy

Scientific Data
Chemotherapeutic drugs will affect the process of spermatogenesis. However, most current studies on the effects of chemotherapeutic drugs on spermatogenesis are based on mouse models, with a shortage of human body evidence.
Jian Cao, Xueheng Zhao, Zailong Qin, Shanshan Lv, Lin Du, Zhizhong Liu, Liqing Fan, Hao Bo   +7 more
doaj   +1 more source

In vitro spermatogenesis: A century‐long research journey, still half way around

Reproductive Medicine and Biology, 2018
Background Spermatogenesis is one of the most complicated cellular differentiation processes in a body. Researchers struggled to find and develop a micro‐environmental condition that can support the process in vitro.
Mitsuru Komeya, Takuya Sato, Takehiko Ogawa   +2 more
doaj   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis

Nature Communications, 2018
Male gametes are generated through a specialised differentiation pathway involving a series of developmental transitions that are poorly characterised at the molecular level.
Christina Ernst, Nils Eling, C. Martinez-Jimenez, J. Marioni, D. Odom   +4 more
semanticscholar   +1 more source

The role of Musashi protein in spermatogenesis and male infertility

Fiyz̤, 2019
Background: Inactivation of transcription occurs during two phases of spermatogenesis. First, in spermatocytes entering the primary meiosis and the second in round and elongating spermatids.
Zohreh Talebi-Yazdabadi , Kianoush Dormiani , Mahboobeh Forouzanfar, Liana Lachinani , Marzieh Tavalaee , Mohammad Hossein Nasr- Esfahani   +5 more
doaj  

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

The Cytoskeleton in Spermatogenesis.

Reproduction, 2019
As germ cells progress through spermatogenesis, they undergo a dramatic transformation, wherein a single, diploid spermatogonial stem cell ultimately produces thousands of highly specialised, haploid spermatozoa. The cytoskeleton is an integral aspect of
Jessica E. M. Dunleavy, M. O’Bryan, P. Stanton, L. O’Donnell   +3 more
semanticscholar   +1 more source