Results 111 to 120 of about 54,242 (266)

Limited Clinical Impact of Androgen Receptor Repeat Length (CAG and GGC) in Klinefelter Syndrome: A Multivariable Analysis

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS) is characterized by marked phenotypic heterogeneity that might be influenced by genetic modifiers, including androgen receptor (AR) repeat length (CAGn and GGCn). The clinical relevance of these repeat lengths in patients with KS before testosterone replacement therapy (TRT) remains unclear.
Andrea Graziani, Alberto Scala, Maria Santa Rocca, Cinzia Vinanzi, Giuseppe Grande, Andrea Di Nisio, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +8 more
wiley   +1 more source

Impact of FSHB and FSHR Genes Polymorphisms on Hormonal Profile and Sperm Retrieval Outcome in Men With Klinefelter Syndrome: A Clinical–Genetic Predictive Study

Andrology, EarlyView.
ABSTRACT Background Genetic variability within the follicle‐stimulating hormone (FSH)‐related genes might contribute to phenotypic heterogeneity in patients with Klinefelter syndrome (KS), yet its clinical impact on sperm retrieval remains unclear. Objectives To investigate the association between FSHB c.211 G > T and FSHR polymorphisms (c.2039 A > G ...
Andrea Graziani, Giuseppe Grande, Maria Santa Rocca, Massimo Iafrate, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +6 more
wiley   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Intrauterine Growth and Male Reproductive Health: A Follow‐up Study From the Danish National Birth Cohort

Andrology, EarlyView.
ABSTRACT Background Reduced intrauterine growth might affect male reproductive health later in life, however, existing research remain inconclusive. Objectives To investigate the association between placental weight and birthweight Z‐scores and semen characteristics, testes volume, and reproductive hormone levels in young men.
Anne Gaml‐Sørensen, Nis Brix, Andreas Ernst, Sandra Søgaard Tøttenborg, Mette Møller Dornfeldt, Karin Sørig Hougaard, Siri Eldevik Håberg, Mikko Myrskylä, Gunnar Toft, Jens Peter Ellekilde Bonde, Cecilia Høst Ramlau‐Hansen   +10 more
wiley   +1 more source

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, EarlyView.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Improving ARTs: Microfluidics as a Tool for Sperm Selection

Andrology, EarlyView.
ABSTRACT Sperm selection is a critical step in assisted reproductive technology (ART), as sperm quality directly influences embryo quality. In vivo, the female reproductive tract imposes several physical and physiological barriers that favors only the most optimal spermatozoa reaching the fertilization site.
A. Pérez‐Gómez, A. Urriés, J. L. de Pablo, L. Serrano‐Ramón, S. Sanchez, R. Herrer, J. M. Morrell, C. Malo   +7 more
wiley   +1 more source

Maternal Consumption of Artificially Sweetened Beverages in Pregnancies and Biomarkers of Fecundity in Adult Sons

Andrology, EarlyView.
ABSTRACT Introduction Maternal intake of artificial sweeteners in beverages (ASB) during pregnancy may have a programming effect on offspring health, including biomarkers of male fecundity. Objective We investigated whether maternal intake of ASB during pregnancy was associated with biomarkers of male fecundity in adult sons.
Frida Vinther Hauberg, Emilie Marquart Hviid, Mette Viola Stokholm, Anne Gaml‐Sørensen, Anne Ahrendt Bjerregaard, Thorhallur I. Halldorsson, Sandra Søgaard Tøttenborg, Cecilia Høst Ramlau‐Hansen   +7 more
wiley   +1 more source

Metabolic pathways fueling human spermatozoa capacitation and hyperactivation: a roadmap for spermatozoa bioenergetics. [PDF]

Front Endocrinol (Lausanne)
Gonçalves EV, Carrageta DF, Guerra-Carvalho B, Sousa M, Bernardino RL.   +4 more
europepmc   +1 more source

Diabetes‐Induced Testicular Injury: Potential Protective Roles of Curcumin, Garcinia kola, and Momordica charantia in Rats

Andrology, EarlyView.
ABSTRACT Background Diabetes mellitus (DM) induces multifaceted cellular and structural alterations in the male reproductive system, thereby predisposing to infertility. Objectives This study aimed to evaluate the morphological, stereological, biochemical, histopathological, and ultrastructural changes induced by DM in testicular tissue, and to ...
Ayşenur Kaya Mutlu, Süleyman Kaplan
wiley   +1 more source