Results 11 to 20 of about 38,872 (182)

CRISPR/Cas9‐mediated genome editing reveals seven testis‐enriched transmembrane glycoproteins dispensable for male fertility in mice

Andrology, EarlyView., 2023
Abstract Background Mammalian fertilization is mediated by multiple sperm acrosomal proteins, many of which are testis‐enriched transmembrane glycoproteins expressed during spermiogenesis (e.g., Izumo sperm‐egg fusion 1, Sperm acrosome associated 6, and Transmembrane protein 95).
Yo Ogawa, Yonggang Lu, Daiji Kiyozumi, Hsin‐Yi Chang, Masahito Ikawa   +4 more
wiley   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Micro‐ and Nano‐Bots for Infection Control

Advanced Materials, EarlyView.
This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady, Shadman Khan, Hong Han, Wei Gao, Zeinab Hosseinidoust, Tohid F. Didar   +5 more
wiley   +1 more source

Isolation Techniques of Micro/Nano‐Scaled Species for Biomedical Applications

Advanced Science, EarlyView.
Separating micro/nano‐scale bioparticles from samples is essential for disease diagnosis, prevention, and monitoring. Therefore, a comprehensive overview of the latest advanced separation technologies is provided, and characteristics and limitations based on six key performance parameters, including purity, recovery rate, throughput, resolution, size ...
Qing Lu, Zhinan Zhang, Xianting Ding
wiley   +1 more source

A Magnetically Transformable Twisting Millirobot for Cargo Delivery at Low Reynolds Number

Advanced Intelligent Systems, EarlyView.
Herein, a soft millirobot, TwistBot, that transforms from a flat shape to a helical shape to propel in fluids at low Reynolds number is reported. Its geometry is optimized by numerical simulation and validated by experiments to effectively propel and deliver solid cargos.
Moonkwang Jeong, Jiyuan Tian, Meng Zhang, Tian Qiu   +3 more
wiley   +1 more source

Compound Heterozygous Variants in ZSWIM7 Gene Linked to Infertility and Its Role in Gonadal Development

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This study aims to elucidate the role of the ZSWIM7 gene in the etiology of infertility, focusing on its potential association with premature ovarian insufficiency and azoospermia. We investigated an 18‐year‐old female patient who presented with primary amenorrhea, hypoplasia of the uterus and ovaries, Tanner stage II breast and pubic hair ...
Denise M. Christofolini, Guilherme Pinn, Thainá Vilella, Maria I. Melaragno, Mariana Moysés‐Oliveira, Luciano Pompei, Rare Genomes Project Consortium, Bianca Bianco, Caio P. Barbosa   +8 more
wiley   +1 more source

The ductal network in the human testis and epididymis: What belongs to which?

Clinical Anatomy, EarlyView.
Abstract The testes and epididymis are traversed by a system of tubules in which sperm cells are generated, matured, nourished, and transported. Among these are the efferent ductules, which connect the rete testis to the duct of the epididymis. In the Terminologia Anatomica (TA), the efferent ductules are assigned to the testicles, while numerous ...
Andreas Gocht, Axel Stuart Merseburger, Süleyman Ergün, Marie Christine Roesch   +3 more
wiley   +1 more source

Myosin VI Is Associated With the Endoplasmic Reticulum in Regions of Sertoli Cells Containing Tubulobulbar Complexes

Cytoskeleton, EarlyView.
ABSTRACT Myosin VI has been reported by others to localize in association with various regions of apical tubulobulbar complexes (TBCs) at sites of attachment between Sertoli cells and late spermatids in the mouse. Tubulobulbar complexes internalize “intact” intercellular junctions during sperm release and during spermatocyte translocation through the ...
Samuel Tretjakov, Prunveer Palia, A. Wayne Vogl   +2 more
wiley   +1 more source

TRiC Is a Structural Component of Mammalian Sperm Axonemes

Cytoskeleton, EarlyView.
ABSTRACT The TRiC chaperonin is responsible for folding ~5%–10% of the proteome in eukaryotic cells. Our recent cryo‐electron microscopy studies of axonemes from diverse mammalian cell types led to the surprising discovery that a fully assembled TRiC chaperonin is a structural component of mammalian sperm flagella, where it is tethered to the radial ...
Alan Brown, Miguel Ricardo Leung, Tzviya Zeev‐Ben‐Mordehai, Rui Zhang   +3 more
wiley   +1 more source