Results 141 to 150 of about 71,184 (285)

A missense mutation in Muc2 promotes gut microbiome and metabolome-dependent colitis-associated tumorigenesis. [PDF]

J Clin Invest
Verna G, De Santis S, Islam BN, Sommella EM, Licastro D, Zhang L, De Almeida Celio F, Miller EN, Merciai F, Caponigro V, Xin W, Campiglia P, Pizarro TT, Chieppa M, Cominelli F.   +14 more
europepmc   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Multiscale measurement for infrared suppression ratio of SPFs-integrated EUV collectors by a weighted harmonic mean integral

Hao Jin, Yuejing Qi, Jing Ma, Qi Wei, Bitao Su, Xin Zhou, Zheng Zhao, Tian-Bing Xu   +7 more
openalex   +1 more source

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

Gut microbiota dysbiosis exacerbates acute pancreatitis via <i>Escherichia coli</i>-driven neutrophil heterogeneity and NETosis. [PDF]

Gut Microbes
Zou Y, Li N, Li X, Kuang M, Xu X, Guan L, Li X, Zheng P, Li L, Wan J, Lu N, Liu J, He C, Zhu Y.   +13 more
europepmc   +1 more source

Early Detection of Chemotherapy‐Induced Glucose Metabolic Alterations in Bladder Carcinoma Using Deuterium (2H) Metabolic Imaging: in Vitro and in Vivo Assessments

Advanced Science, EarlyView.
This study presents the first application of deuterium metabolic imaging (DMI) for assessing therapeutic response in bladder cancer. Employing [2,3,4,6,6′‐2H5]‐D‐glucose, DMI successfully identified chemotherapy‐induced suppression of glycolysis both in vitro and in vivo.
Lingmin Kong, Ganghan Yang, Bei Weng, Zhihua Wen, Joshua D. Kaggie, Qian Cai, Qian Wan, Cuien Zheng, Feng Du, Ye Li, Xin Liu, Ferdia A. Gallagher, Yan Guo, Shi‐Ting Feng, Chao Zou, Huanjun Wang   +15 more
wiley   +1 more source

Pengaruh Budaya Sekolah Terhadap Karakter Siswa di UPT SPF SD Inpres Unggulan BTN Pemda Kota Makassar

, 2023
Nova Elvianti, Jusmawati Jusmawati, Eka Fitriana HS, Cayati Cayati   +3 more
openalex   +2 more sources

Real‐Time In Vivo Cellular‐Level Imaging During Puncture

Advanced Science, EarlyView.
We present an artificial‐intelligence‐empowered integrative‐light‐field microendoscopy (AIM) needle that delivers real‐time in vivo, diffraction‐limited cellular‐level imaging during puncture and visualizes layered microstructures along the needle path. As a microscopic complement to CT/ultrasound, it improves sampling localization and adds preliminary
Huifang Gao, Jiakang Shao, Quanzhi Li, Yizhou Tan, Liangliang Huang, Xiaorong Xu, Ji Qi, Julin Xiao, Wenwen Li, Zhong Wen, Le Wang, Xu Liu, Qing Yang, Ying Gu   +13 more
wiley   +1 more source

Diagnosis and treatment of subarachnoid-pleural fistula following thoracic spine surgery: a case series study and systematic literature review. [PDF]

J Orthop Surg Res
Zhu F, Zhao R, Zhang Y, Ling L, Wang J, Huang B.   +5 more
europepmc   +1 more source

The influence of age on the response of SPF hens to infection with Salmonella enteritidis PT4 [PDF]

, 1991
T. J. Humphrey, H. Chart, A. Baskerville, B. Rowe   +3 more
openalex   +1 more source