Results 151 to 160 of about 71,184 (285)

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Virulence and transmission characteristic of H3N8 avian influenza virus circulating in chickens in China. [PDF]

Virulence
Mei M, Zhang X, Wu Q, Xu M, Zhao Y.
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Quantitative Surface-Enhanced Raman Spectroscopy: Challenges, Strategies, and Prospects. [PDF]

Molecules
Lu Z, Wang J, Yan S.
europepmc   +1 more source

Efektivitas Model Pembelajaran Project Based Learning (Pjbl) Pada Pembelajaran Matematika Di Kelas V UPT SPF SD Inpres Andi Tonro Kota Makassar

, 2023
Muttahara Sabir, Sitti Fithriani Saleh, Kristiawati   +2 more
openalex   +2 more sources

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Knowledge, Attitudes and Practice of Iranian Patients on Sunscreen Application. [PDF]

J Cosmet Dermatol
Yazdanparast T, Kashani MN, Babakhani S, Nasrollahi SA, Amiri F, Kassir M, Firooz A.   +6 more
europepmc   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Intratumoral microbiota-derived S1P sensitizes the combination therapy of capecitabine and PD-1 inhibitors. [PDF]

iScience
Dai CS, Qi TT, Shang HL, Xie RH, Liu H, Liu ZM, Cui YM, Zhang YH.   +7 more
europepmc   +1 more source

Indicateurs de qualité du soin nutritionnel en oncologie, SPF Plan Cancer

, 2014
Aude Anzevui, Brigitte Bertrand
openalex   +1 more source