Results 11 to 20 of about 359,437 (296)

Human Corneal Endothelial Cell Precursors Isolated by Sphere-Forming Assay

Investigative Opthalmology & Visual Science, 2005
To isolate precursors of human corneal endothelial cells (HCECs) in vitro.HCECs were subjected to a sphere-forming assay in which spheres floated in serum-free medium containing growth factors. To promote differentiation, the isolated sphere colonies were plated in dishes coated with poly-L-lysine (PLL)/laminin or fetal bovine endothelium extracellular
Seiichi, Yokoo, Satoru, Yamagami, Yasuo, Yanagi, Saiko, Uchida, Tatsuya, Mimura, Tomohiko, Usui, Shiro, Amano   +6 more
openaire   +3 more sources

Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro

Medicina, 2022
Background and Objectives: Clinically used concentrations of sevoflurane, an inhaled anesthetic, have been reported to significantly inhibit tumor growth.
Tomohiro Shoji, Mikio Hayashi, Chisato Sumi, Munenori Kusunoki, Takeo Uba, Yoshiyuki Matsuo, Kiichi Hirota   +6 more
doaj   +2 more sources

Evidence of progenitor cells in the adult human cochlea: sphere formation and identification of ABCG2

Clinics, 2017
OBJECTIVES: The aim of this study was to search for evidence of stem or progenitor cells in the adult human cochlea by testing for sphere formation capacity and the presence of the stem cell marker ABCG2.
Milene Massucci-Bissoli, Karina Lezirovitz, Jeanne Oiticica, Ricardo Ferreira Bento   +3 more
doaj   +2 more sources

Iron affects the sphere-forming ability of ovarian cancer cells in non-adherent culture conditions

Frontiers in Cell and Developmental Biology, 2023
Introduction: Detachment from the extracellular matrix (ECM) is the first step of the metastatic cascade. It is a regulated process involving interaction between tumor cells and tumor microenvironment (TME).
A. M. Battaglia, A. Sacco, Eleonora Vecchio, Stefania Scicchitano, Lavinia Petriaggi, Emanuele Giorgio, Stefania Bulotta, Sonia Levi, C. Faniello, F. Biamonte, Francesco Costanzo   +10 more
semanticscholar   +1 more source

SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1

Cancer Cell International, 2020
Background Cancer stem cells (CSCs) have been recognized as an important drug target, however, the underlying mechanisms have not been fully understood. SKP1 is a traditional drug target for cancer therapy, while, whether SKP1 promotes colorectal cancer (
Cong Tian, Tingyuan Lang, Jiangfeng Qiu, Kun Han, Lei Zhou, Daliu Min, Zhiqi Zhang, Dachuan Qi   +7 more
doaj   +1 more source

NCAPG stimulates lung adenocarcinoma cell stemness through aerobic glycolysis

The Clinical Respiratory Journal, 2023
Background Cancer stem cells are pivotal in cancer progression and therapy, including lung adenocarcinoma (LUAD). High NCAPG level is implicated in malignant tumorigenesis, but investigations on NCAPG and LUAD stem cells are warranted.
Zuwang Zhang, Dongdong Qi, Xun Liu, Poming Kang   +3 more
doaj   +1 more source

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]

, 2009
BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P, Goldstein, Andrew S, Hahm, Scott A, Haider, Maahum, Head, Christian S, Perner, Sven, Reiter, Robert E, Rubin, Mark A, Sun, Wenyi, Tran, Chau P, Witte, Owen N, Zhang, Bao   +11 more
core   +1 more source

Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDHhighCD44+ phenotype and sphere-forming capacity

BMC Cancer, 2014
BackgroundConventional chemotherapy in malignant pleural mesothelioma (MPM) has minimal impact on patient survival due to the supposed chemoresistance of cancer stem cells (CSCs).
L. Cortes-Dericks, L. Froment, Ruben Boesch, R. Schmid, G. Karoubi   +4 more
semanticscholar   +2 more sources

NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells. [PDF]

PLoS ONE, 2018
Accumulating evidence demonstrated that NANOG1, the key transcription factor for embryonic stem cells, is associated with human cancers. NANOGP8, one of the pseudogenes in NANOG gene family, contains an intact open reading frame and also said to be ...
Xia Ma, Bei Wang, Xiaofang Wang, Yujiao Luo, Wufang Fan   +4 more
doaj   +1 more source

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]

, 2016
The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela, DI PAOLO, Virginia, Giampaolo, Adele, Gravina, GIOVANNI LUCA, Hassan, Hamisa Jane, Macioce, Giampiero, Marampon, Francesco, Milazzo, Luisa, Tombolini, Vincenzo, Vulcano, Francesca, Zani, Bianca Maria   +10 more
core   +9 more sources