Results 41 to 50 of about 359,437 (296)

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. [PDF]

, 2018
Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are ...
Day, Emily S, Gleghorn, Jason P, Ioele, Stephen A, Melamed, Jilian R, Morgan, Joshua T, Sims-Mourtada, Jennifer   +5 more
core   +1 more source

Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine. [PDF]

, 2015
Various protocell models have been constructed de novo with the bottom-up approach. Here we describe a silica-based protocell composed of a nanoporous amorphous silica core encapsulated within a lipid bilayer built by self-assembly that provides for ...
Brinker, C Jeffrey, Jakobsson, Eric, Sun, Jie, Wang, Yingxiao   +3 more
core   +2 more sources

Circular RNA_0000326 accelerates breast cancer development via modulation of the miR-9-3p/YAP1 axis.

Neoplasma (Bratislava), 2023
Circular RNA (circ)_0000326 has been reported in bladder cancer and cervical cancer and is concerned to be involved with the development of cancerous cells.
Xiaohui Xue, Shuai Zhao, Meng-Chang Xu, Ying Li, Wen-Fei Liu, H. Qin   +5 more
semanticscholar   +1 more source

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells [PDF]

, 2015
Tumor-initiating cells constitute a population within a tumor mass that shares properties with normal stem cells and is considered responsible for therapy failure in many cancers.
AMENDOLA, Donatella, Bearzi, Claudia, Bucci, Barbara, Camerlingo, Rosalba, CARICO, ELISABETTA, D'Agnano, Igea, DOMINICI, Carlo, Felsani, Armando, Guglielmi, Loredana, Iannetti, Ilaria, Leonetti, Carlo, MARESCA, GIOVANNA, MEGIORNI, Francesca, Mercanti, Delio, MILAN, MARIKA, Musa, Carla, Nardella, Marta, Pirozzi, Giuseppe, Porru, Manuela, Rizzi, Roberto, Sessa, Giuseppe   +20 more
core   +2 more sources

Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells. [PDF]

, 2014
IntroductionAlthough breast phyllodes tumors are rare, there is no effective therapy other than surgery. Little is known about their tumor biology.
Chou, Fen-Pi, Huang, Chiun-Sheng, Hung, Jung-Tung, Liao, Guo-Shiou, Lien, Huang-Chun, Lin, Jin-Jin, Lin, Ruey-Jen, Yeh, Kun-Tu, Yu, Alice L, Yu, John   +9 more
core   +3 more sources

Lack of correlation of stem cell markers in breast cancer stem cells [PDF]

, 2014
BACKGROUND: Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
A M Thompson, AM Thompson, C Calabrese, C Ginestier, C Scheel, C Sheridan, CE Eyler, CL Chaffer, CM Fillmore, E Charafe-Jauffret, E Resetkova, EY Tan, F Vaillant, G Farnie, G Kristiansen, G Rappa, H Harrison, H Korkaya, J Stingl, J Zhou, JC Lawson, JM Rosen, K Engelmann, K He, K Murray, M Al-Hajj, M Boylan, M Christgen, M Kok, M Pajic, M V Appleyard, MA Ahmed, ME Prince, MH Wright, MJ Grimshaw, MV Appleyard, O Al-Assar, O Leis, O Moussa, P J Coates, P Kabos, R Nenutil, S Bao, S Liu, SY Kim, SY Park, T Tanei, TM Phillips, WW Hwang-Verslues, Y Liu   +49 more
core   +4 more sources

Olea europaea Leaf Phenolics Oleuropein, Hydroxytyrosol, Tyrosol, and Rutin Induce Apoptosis and Additionally Affect Temozolomide against Glioblastoma: In Particular, Oleuropein Inhibits Spheroid Growth by Attenuating Stem-like Cell Phenotype

Life, 2023
The effects of Olea europaea leaf extract (OLE) phenolics, including oleuropein (OL), hydroxytyrosol (HT), tyrosol (TYR), and rutin against glioblastoma (GB), independently and in combination with temozolomide (TMZ), were investigated in T98G and A172 ...
M. Erçelik, Ç. Tekin, G. Tezcan, Seçil Ak Aksoy, A. Bekar, H. Kocaeli, M. O. Taşkapılıoğlu, P. Eser, B. Tunca   +8 more
semanticscholar   +1 more source

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

Cancer Cell International, 2020
Background Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable and vague, and the metabolomics ...
Feng Wang, Zhiyu Zhang, Qin Li, Tao Yu, Chengbin Ma   +4 more
doaj   +1 more source

Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer [PDF]

, 2019
This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical
Broman, Meaghan M., Chang, Lei, Chowdhury, Dipanjan, Cresswell, Gregory, He, Yizhou J., Jacobsen, Max, McGuire, Callista, Nikhil, Kumar, Ratliff, Timothy L., Sandusky, George E., Satapathy, Shakti R., Shah, Kavita, Tandiary, Michael, Viccaro, Keith   +13 more
core   +1 more source

Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. [PDF]

, 2017
Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors.
Dai, Jin, Guan, Wei, Hu, Junhui, Liu, Peijun, Qian, Yuan, Sharrow, Allison C, Tang, Kun, Wu, Lily, Xiao, Haibing, Xu, Hua, Ye, Zhangqun   +10 more
core   +3 more sources