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Bioinspired Dormant-ATP-Stabilized Biomineral Amorphous Nanoparticles and Saliva-Activated Rapid Mineralization Toward High-Performance Dental Enamel Restoration. [PDF]
Adv Healthc MaterLi SY, Zhu YJ, Li H, Yu HP.
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Spherical Crystallization of Celecoxib
Drug Development and Industrial Pharmacy, 2002Celecoxib exhibits poor flow properties and compressibility. Spherical crystallization of celecoxib was carried out using the solvent change method. An acetone:dichloromethane (DCM):water system was used where DCM acted as a bridging liquid and acetone and water as good and bad solvent, respectively.
A R, Paradkar +4 more
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Spherical Crystallization: An Overview
International Journal of Drug Delivery Technology, 2014 Introduction: In 1986, Kawashima developed the spherical crystallization technique for size enlargement of drugs in the field of pharmacy. Spherical crystallization is defined as “An agglomeration process that transforms crystalline drug directly into compact spherical forms for improving the flowability, solubility and compactability”.
Sumant Saini
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Spherical Crystallization of Mebendazole to Improve Processability
Pharmaceutical Development and Technology, 2008Spherical crystallization technique combines crystallization and agglomeration directly to generate spherical crystals with improved micromeretic properties, thus obviating need for further processing by granulation and agglomeration. The present study was focused on spherical crystallization of an antihelmentic drug - Mebendazole (MBZ) - using ...
Arvind Bansal, Garima Chawla
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Spherical crystallization of benzoic acid
International Journal of Pharmaceutics, 2008 This paper deals with the development of a method for spherical crystallization of benzoic acid. Benzoic acid is dissolved in ethanol, water is used as anti-solvent and chloroform is used as bridging liquid. After an introductory screening of different methods, the influence of the amount of the bridging liquid, the solute concentration and the ...
Jyothi, Katta, Ake C, Rasmuson
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Crystal growth of drug materials by spherical crystallization
Journal of Crystal Growth, 2002One of the crystal growth processes is the production of crystal agglomerates by spherical crystallization. Agglomerates of drug materials were developed by means of non-typical (magnesium aspartate) and typical (acetylsalicylic acid) spherical crystallization techniques.
Piroska Szabo-Revesz +2 more
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Is spherical crystallization without additives possible? [PDF]
Chemical Engineering Research and Design, 2010 The quasi-emulsion solvent diffusion method of sphericalcrystallization consists in producing in one step crystallization and agglomeration of small crystals in droplets of an emulsion.
Beatrice Biscans, Sébastien Teychene
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Science, 1982
Direct spherical agglomeration of salicylic acid crystals during crystallization is described. The needle-like salicylic acid crystals simultaneously form and agglomerate in a mixture of three partially miscible liquids, such as water, ethanol, and chloroform, with agitation. The agglomerates can be made directly into tablets because of their excellent
Y, Kawashima, M, Okumura, H, Takenaka
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Direct spherical agglomeration of salicylic acid crystals during crystallization is described. The needle-like salicylic acid crystals simultaneously form and agglomerate in a mixture of three partially miscible liquids, such as water, ethanol, and chloroform, with agitation. The agglomerates can be made directly into tablets because of their excellent
Y, Kawashima, M, Okumura, H, Takenaka
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Crystallization of Deformable Spherical Colloids
Physical Review Letters, 2010We introduce and characterize a first-order model for a generic class of colloidal particles that have a preferred spherical shape but can undergo deformations while always maintaining hard-body interactions. The model consists of hard spheres that can continuously change shape at fixed volume into prolate or oblate ellipsoids of revolution, subject to
Vera M O, Batista, Mark A, Miller
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