Results 151 to 160 of about 343,323 (262)

Evolution of the frontal aslant tract and implications for primate vocalization and human speech

Nature Communications
Monkeys, chimpanzees and humans share dorsomedial and ventrolateral frontal regions for vocalization, yet only humans have speech. These regions are interconnected by the frontal aslant tract (FAT), a pathway increasingly recognized as central to speech ...
Salvatore Citro, Matt S. Dawson, Ahmad Beyh, Flavio Dell’Acqua, Carlo Cavaliere, Tim B. Dyrby, Kristine Krug, Maurice Ptito, Lorenzo Carnevale, Sergio Della Sala, William D. Hopkins, Marsel M. Mesulam, Marco Catani   +12 more
doaj   +1 more source

Regularized spherical deconvolution

The objective of this research is to compute a regularized nonparametric deconvolution density estimator on the two dimensional unit sphere 'S'² in three-dimensional Euclidean space R3 . It is assumed that the recorded observations are the result of the convolution of true measurements with noise, and to recover true measurements, a deconvolution ...
openaire   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

Does one size fit all? Reconstructing crossing fibers in diffusion MRI using spherical deconvolution with local response functions

We present Local Spherical Deconvolution (LSD), a diffusion MRI deconvolution method to reconstruct crossing fiber directions in the brain. In contrast to previous approaches which assumed a single deconvolution kernel for the entire brain, LSD utilizes ...
Jäger, C., Weiskopf, N. ; https://orcid.org/, Eichner, C. ; https://orcid.org/, Paquette, M. ; https://orcid.org/, Crockford, C., Friederici, A. ; https://orcid.org/, Möller, T., Gerbeth, H., Gallardo, G. ; https://orcid.org/, Anwander, A. ; https://orcid.org/, Bock, C., Wittig, R.   +11 more
core  

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Implicit neural representation of multi-shell constrained spherical deconvolution for continuous modeling of diffusion MRI. [PDF]

Imaging Neurosci (Camb)
Hendriks T, Vilanova A, Chamberland M.
europepmc   +2 more sources

dbenson5225/Deconvolution: Deconvolution version 1.0

<p>Matlab software and data for deconvolution detailed by Gambill et al., Exploring the influence of channel intermittency and discharge on transient storage in stream systems: Insights from multiple logjams and channels, submitted to Water ...
dbenson5225
core   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source